EP CAMPBELL BIO.FOCUS-MOD.MASTER.(18WK)
EP CAMPBELL BIO.FOCUS-MOD.MASTER.(18WK)
3rd Edition
ISBN: 9780136781851
Author: Urry
Publisher: PEARSON CO
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Chapter 9, Problem 5TYU

The drug cytochalasin B blocks the function of actin. Which of the following aspects of the animal cell cycle would be most disrupted by cytochalasin B?

  1. A.    spindle formation
  2. B.     spindle attachment to kinetochores
  3. C.     cell elongation during anaphase
  4. D.    cleavage furrow formation and cytokinesis
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Which of the following statements about the cell cycle is TRUE?   a. The protein APC blocks cells from entering anaphase   b. CDKs are degraded after each cell cycle phase by the addition of a ubiquitin chain to the proteins   c. A kinase is a protein that adds a ubiquitin chain to other proteins Cyclin activity is necessary, but not always sufficient, for CDK activation   d. Cyclin proteins must be degraded before Cdk proteins can be activated
The diagram below shows a model for the normal regulation of the transition to anaphase during mitosis. 1. Signals are released by unattached kinetochores that cause MAD to bind CDC20. MAD CDC20 6. Chromatids separate as mitosis procoeds to anaphase. COHESIN 3. The APCCDC20 CDC20 complex ubiquinates Securin. APC 2. When all kinetochores are attached, MAD releases CDC20 which then combines with APC UBIQUITIN SEPARASE . Separase destroys Cohesin APC SEPARASE SECURIN 4. Securin is destroyed, releasing Separase Your analyses of cancer cells that do not regulate this transition normally indicate that: MAD is binding to CDC20; • Ubiquitin is not attached to securin; • Sister chromatids separate and move to opposite poles of the cell. Which of the following explanations could account for all of your observations? a. The cell has an alteration in MAD that prevents it from releasing CDC20 when the 'unattached kinetochore' signal stops. O b. More than one of the other answer choices are correct.…
Which of the following statements about mitosis is incorrect? a. Microtubules from the spindle poles attach to the kinetochores on the chromosomes. b. In anaphase, the spindle separates sister chromatids and pulls them apart. c. In metaphase, spindle microtubules align the chromosomes at the spindle midpoint. d. Cytokinesis describes the movement of chromosomes. e. Both the animal cell furrow and the plant cell plate form at their former spindle midpoint.

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