Microbiology With Diseases By Taxonomy (6th Edition)
6th Edition
ISBN: 9780134832302
Author: Robert W. Bauman Ph.D.
Publisher: PEARSON
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Chapter 9, Problem 5CT
Over 1000 people developed severe diarrhea, and at least four died, from a strain of Salmonella enterica in the fall of 2012. Epidemiologists determined that infection resulted from the consumption of contaminated smoked salmon. Based on this chapter, what methods to control microbial growth are available to fishermen, packers, and stores that might have prevented such an outbreak? What other precautions could consumers have taken?
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 9 Solutions
Microbiology With Diseases By Taxonomy (6th Edition)
Ch. 9 - Why does milk eventually go bad despite being...Ch. 9 - Why are BSL-4 suits pressurized? Why not just wear...Ch. 9 - Prob. 3TMWCh. 9 - Prob. 4TMWCh. 9 - Prob. 1EDCSCh. 9 - Prob. 2MCCh. 9 - Prob. 3MCCh. 9 - Prob. 4MCCh. 9 - Prob. 5MCCh. 9 - The endospores or which organism can be used as a...
Ch. 9 - A company that manufactures an antimicrobial...Ch. 9 - Prob. 8MCCh. 9 - Prob. 9MCCh. 9 - Prob. 10MCCh. 9 - Prob. 11MCCh. 9 - Which of the following adjectives best describes a...Ch. 9 - Biosafety Level 3 includes ________. a. double...Ch. 9 - Prob. 14MCCh. 9 - Prob. 15MCCh. 9 - Prob. 16MCCh. 9 - Prob. 17MCCh. 9 - Prob. 18MCCh. 9 - Prob. 19MCCh. 9 - Prob. 20MCCh. 9 - Prob. 1SACh. 9 - Compare and contrast four tests that have been...Ch. 9 - Prob. 3SACh. 9 - Prob. 4SACh. 9 - Prob. 5SACh. 9 - Describe five physical methods of microbial...Ch. 9 - Prob. 7SACh. 9 - Prob. 8SACh. 9 - Prob. 9SACh. 9 - Compare and contrast the action of alcohols,...Ch. 9 - Prob. 11SACh. 9 - Why are alcohols more effective in a 70% solution...Ch. 9 - Contrast the structures and actions of soaps and...Ch. 9 - What are some advantages and disadvantages of...Ch. 9 - Prob. 15SACh. 9 - Calculate the decimal reduction time (D) for the...Ch. 9 - Prob. 2VICh. 9 - Prob. 1CTCh. 9 - Is desiccation the only antimicrobial effect...Ch. 9 - Prob. 3CTCh. 9 - Prob. 4CTCh. 9 - Over 1000 people developed severe diarrhea, and at...Ch. 9 - An over-the-counter medicated foot powder contains...Ch. 9 - Prob. 7CTCh. 9 - Prob. 8CTCh. 9 - Explain why quaternary ammonium compounds are not...Ch. 9 - Prob. 10CTCh. 9 - Would you expect Gram-negative bacteria or...Ch. 9 - Where should you place a sterilization indicator...Ch. 9 - Why is liquid water necessary for microbial...Ch. 9 - Prob. 14CTCh. 9 - During the fall 2001 bioterrorist attack in which...Ch. 9 - Prob. 16CTCh. 9 - Prob. 17CT
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