Chapter 9, Problem 4PI

Summary Introduction

To determine: The way in which calsequestrin (a Ca²⁺-binding protein) enhances the excitation-contraction coupling process when it is present in high concentration in the terminal cisternae.

Introduction: During skeletal muscle contraction, a motor neuron stimulates the skeletal muscle fibers. The stimulation of skeletal muscle fibers ultimately causes the interaction between the myofilaments within the skeletal muscle fibers to produce a surface tension between the muscles. Excitation–contraction coupling is an event that involves T-tubules, sarcolemma, and sarcoplasmic reticulum.