EBK BIOCHEMISTRY
EBK BIOCHEMISTRY
6th Edition
ISBN: 8220102959286
Author: GRISHAM
Publisher: CENGAGE L
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Chapter 9, Problem 25P

Answers to all problems are at the end of this book. Detailed solutions are available in the Student Solutions Manual, Study Guide, and Problems Book.

Exploring the Mechanism of Lipid Transport by a Flippase ATP-dependent flippases art closely related in their structures to ion pumps like the plasma membrane Na+, K+-ATPase and sarcoplasmic reticulum Ca2+-ATPase, but they contend with a novel dilemma not shared by the ion transport systems. Consult the following reference and. summarize the structural features common to the flippases and P-type ATPases, and describe how the flippase solves the "giant substrate problem". (Vestegaard, A.L., Coleman, J.A., Lemmin. T., et al., 2014. Critical roles of roles ucine-364 and adjacent residues in a hydrophobic gate control of phospholipid transport by the mammalian P4-ATPase ATPSA2. Proceedings of the National Academy of Sciences, USA 111:16629-16633.)

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