Biological Science, Books a la Carte Plus Mastering Biology with Pearson eText -- Access Card Package (6th Edition)
Biological Science, Books a la Carte Plus Mastering Biology with Pearson eText -- Access Card Package (6th Edition)
6th Edition
ISBN: 9780134296029
Author: Scott Freeman, Kim Quillin, Lizabeth Allison, Michael Black, Greg Podgorski, Emily Taylor, Jeff Carmichael
Publisher: PEARSON
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Chapter 9, Problem 11PIAT

Chapter 9, Problem 11PIAT, Does the Fountain of Youth spring from the mitochondrial proton gradient? For thousands of years,

Does the Fountain of Youth spring from the mitochondrial proton gradient?

For thousands of years, explorers have sought mythical waters that promote a long life. In modern times, the quest for extending the human life span continues. Current research points to changes in the mitochondrial electron transport chain and the proton gradient as a cause of aging. How is the ETC involved in aging? Can it be manipulated to increase longevity?

Research has shown that cellular damage associated with aging occurs via the formation of oxygen radicals called reactive oxygen species (ROS). These radicals are produced when an excessive proton gradient across the inner mitochondrial membrane slows down the rate of electron transport in the ETC. Propose a hypothesis to explain how a proton gradient can reduce the rate of electron transport.

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Mitochondrial mutations; Author: Useful Genetics;https://www.youtube.com/watch?v=GvgXe-3RJeU;License: CC-BY