EBK RESEARCH METHODS FOR THE BEHAVIORAL
EBK RESEARCH METHODS FOR THE BEHAVIORAL
6th Edition
ISBN: 8220106720271
Author: Forzano
Publisher: YUZU
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Chapter 8.2, Problem 3LO

Define individual differences and explain how individual differences between groups and confounding from environmental variables can threaten the internal validity of a between-subjects design.

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Can you explain this statement below in layman's terms?   Secondary Analysis with Generalized Linear Mixed Model with clustering for Hospital Center and ICUvs Ward EnrolmentIn a secondary adjusted analysis we used generalized linear mixed models with random effects forcenter (a stratification variable in the primary analyses). In this analysis, the relative risk for the primaryoutcome of 90-day mortality for 7 versus 14 days of antibiotics was 0.90 (95% Confidence Interval [CI]0.78, 1.05).
In a crossover trial comparing a new drug to a standard, π denotes the probabilitythat the new one is judged better. It is desired to estimate π and test H0 : π = 0.5against H1 : π = 0.5. In 20 independent observations, the new drug is better eachtime.(a) Find and plot the likelihood function. Give the ML estimate of π (Hint: youmay use the plot function in R)
Can you explain what this analysis means in layman's terms?   - We calculated that a target sample size of 3626, which was based on anticipated baseline 90-day mortality of 22% and a noninferiority margin of no more than 4 percentage points, would give the trial 80% power, at a one-sided alpha level of 2.5%, accounting for a maximum of 5% loss to follow-up and for early stopping rules for three interim analyses.-
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