EBK MOLECULAR CELL BIOLOGY
EBK MOLECULAR CELL BIOLOGY
8th Edition
ISBN: 8220103601887
Author: LODISH
Publisher: YUZU
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Chapter 8, Problem 8RTC
Summary Introduction

To analyze:

The definition of the nucleosome and the role of histones in nucleosome. The arrangement of the nucleosomes in condensed 30nm fibers.

Introduction:

The chromatin material is a long thread like structure that is packed around the proteins to fit itself into a small nucleus. A diploid cell consist of about two meters of DNA while the diameter of a nucleus is about 4-5μm and therefore packaging becomes necessary to fit the DNA into the nucleus.

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You aim to test the hypothesis that the Tbx4 and Tbx5 genes inhibit each other's expression during limb development. With access to chicken embryos and viruses capable of overexpressing Tbx4 and Tbx5, describe an experiment to investigate whether these genes suppress each other's expression in the limb buds. What results would you expect if they do repress each other? What results would you expect if they do not repress each other?
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