EBK HUMAN BIOLOGY
11th Edition
ISBN: 8220100545931
Author: MCMILLAN
Publisher: Cengage Learning US
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Textbook Question
Chapter 8, Problem 5SQ
Which of the following statements about red blood cells is false?
- a. They live about 120 days before being replaced.
- b. They lack a nucleus and other organelles when they are mature.
- c. They are replaced when the hormone EPO stimulates stem cells in bone marrow.
- d. They are replaced as part of a negative feedback loop in which kidney cells monitor blood oxygen levels
- e. All the above statements are true except b, because all cells require a nucleus in order to function properly.
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 8 Solutions
EBK HUMAN BIOLOGY
Ch. 8 - Prob. 1RQCh. 8 - What are the cellular components of blood? Where...Ch. 8 - Prob. 3RQCh. 8 - What is an agglutination response? How can it be...Ch. 8 - Prob. 5RQCh. 8 - Prob. 1SQCh. 8 - Prob. 2SQCh. 8 - Prob. 3SQCh. 8 - In the lungs, the main factor in boosting the...Ch. 8 - Which of the following statements about red blood...
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