EBK INTEG.PRIN.OF ZOOLOGY
EBK INTEG.PRIN.OF ZOOLOGY
18th Edition
ISBN: 9781260411201
Author: HICKMAN
Publisher: MCG COURSE
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Chapter 8, Problem 4RQ

What is meant by the term “activation” in embryology?

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A patient visits her doctor with symptoms typical of a bladder infection. She is immediately prescribed an 800 mgdose of antibiotic (bioavailability = 1/2, t½ = 12 h). The corresponding plasma concentration of drug is found to be 96 micrograms/ml. What is the volume of distribution of this drug? Please round to the nearest liter.
A 10 mg/Kg dose of a drug is given by intravenous injection to a 20 Kg dog. What would the volume of distribution be if the drug had been given orally and only 50% of the drug was absorbed (the concentration of drug at time = 0 is 0.1 mg/L)? Be sure to show your work.
After oral administration of 10mg of a drug, 50% is absorbed and 40% of the amount absorbed is metabolized by the first pass effect. The bioavailable dose of this drug is  ______. Make sure to provide units for your answer. Show your work.
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Embryology | Fertilization, Cleavage, Blastulation; Author: Ninja Nerd;https://www.youtube.com/watch?v=8-KF0rnhKTU;License: Standard YouTube License, CC-BY