EBK BIOLOGY
5th Edition
ISBN: 9780100667976
Author: Maier
Publisher: YUZU
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Chapter 8, Problem 2LTB
Summary Introduction
To detrmine:
The meaning of the sentence,' a gene has multiple allele'.
Whether a gene can have more than two allele for a single trait.
Introduction:
The allele is the form of a single gene present in an organism. The different combination of the alleles determines the genotype and
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calculate the questions showing the solution including variables,unit and equations all the questiosn below using the data
a) B1,
b) B2,
c) hybrid rate constant (1)
d) hybrid rate constant (2)
e) t1/2,dist
f) t1/2,elim
g) k10
h) k12
i) k21
j) initial concentration (C0)
k) central compartment volume (V1)
l) steady-state volume (Vss)
m) clearance (CL) AUC (0→10 min) using trapezoidal rule
n) AUC (20→30 min) using trapezoidal rule
o) AUCtail (AUC360→∞)
p) total AUC (using short cut method)
q) volume from AUC (VAUC)
QUESTION 8
For the following pedigree, assume that the mode of inheritance is X-linked recessive, and that the trait has full penetrance and expressivity and occurs at a very low frequency in the hum
population. Using XA for the dominant allele and Xa for the recessive allele, assign genotypes for the following individuals (if it is not possible to figure out the second allele of a genotype,
that with an underscore):
2
m
1
2
1
2
4 5 6
7
8
9
IV
1 2 3
5 6
7
8
CO
9
10
12 13
V
1,
2 3
4 5 6 7
8 9 10
11 12 13
a. Il-1:
b. 11-2:
c. III-3:
d. III-4:
e. If individuals IV-11 and IV-12 have another child, what is the probability that they will have a boy with the disorder?
Answerr
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