EBK ESSENTIALS OF PATHOPHYSIOLOGY
EBK ESSENTIALS OF PATHOPHYSIOLOGY
4th Edition
ISBN: 9781469893389
Author: PORTH
Publisher: WOLTERS KLUWER HEALTH (COURSE)
Question
Book Icon
Chapter 8, Problem 1RE

A.

Summary Introduction

To determine: The cause of electrolyte disturbance in a patient with AIDS and investigated with Pneumocystis carinii pneumonia.

Introduction: Pneumocystis jirovecii Pneumonia is known as Pneumocystis Carinii Pneumonia and it is a fungal infection that causes inflammation and fluid buildup in an individual’s lungs. This infection is nonseasonal and worldwide. The respiratory route probably acquires the organism.

A.

Expert Solution
Check Mark

Explanation of Solution

Pneumocystis jirovecii pneumonia is often associated with hyponatremia, a kind of dyselectrolytemia, and the level of sodium significantly correlates to the overall outcome of the patient. It is a condition in which the serum sodium levels are less than 135 mEq/L, which results in intracerebral osmotic fluid shifts, brain edema, and several neurological complications.

Hyponatremia in HIV is associated witha syndrome of inappropriate ADH secretion, and common association is with Pneumocystis jirovecii. This yeast-like fungus attaches to the alveolar septal wall replicate, resulting in diffuse alveolitis and impaired oxygenation and causes pneumonia in immunocompromised hosts.

B.

Summary Introduction

To determine: The five cardial features of low serum sodium level and having AIDS.

Introduction: Hyponatremia is the disorder of electrolyte balance and body fluid in patients having Pneumocystis carinii infection along withHIV infection. A cardinal symptom or cardinal sign is the primary or significant clinical sign or symptom by which a diagnosis is made.

B.

Expert Solution
Check Mark

Explanation of Solution

Pneumocystis carinii pneumonia is an opportunistic infection that occurs in immunosuppressed populations having a CD4+ T cell count below 200 cells per µL.

Cardinal findings of patients with immune deficiency disorders who are at particular risk for Pneumocystis carinii pneumonia include thymic dysplasia, cytomegalovirus retinitis, Kaposi sarcoma, oesophageal candidiasis, and Toxoplasma encephalitis. Development of hypogammaglobulinemia with low arterial oxygen tension, arterial pH usually increased, and carbon dioxide retention also occurs.

Want to see more full solutions like this?

Subscribe now to access step-by-step solutions to millions of textbook problems written by subject matter experts!
Students have asked these similar questions
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine: (a) k, C0, V, and AUC* for the bolus iv data  (b) k, ka, B1, and AUC* for the po data  (c) k, ka, B1, and AUC* for the ip data  (d) relative bioavailability for po vs ip, Fpo/Fip  (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip    MAKE SURE ANSWERS HAVE UNITS if appropriate. SHOW ALL WORK, including equation used, variables used and each step to your solution.
2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0  Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present.  Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…
The current nutrition labelling regulation in Hong Kong requires food manufacturer to list E+7 information on the package of pre-packaged food products. Do you think that more nutrients, such as calcium and cholesterol, shall be included?
Knowledge Booster
Background pattern image
Similar questions
SEE MORE QUESTIONS
Recommended textbooks for you
Text book image
Human Anatomy & Physiology (11th Edition)
Biology
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:PEARSON
Text book image
Biology 2e
Biology
ISBN:9781947172517
Author:Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher:OpenStax
Text book image
Anatomy & Physiology
Biology
ISBN:9781259398629
Author:McKinley, Michael P., O'loughlin, Valerie Dean, Bidle, Theresa Stouter
Publisher:Mcgraw Hill Education,
Text book image
Molecular Biology of the Cell (Sixth Edition)
Biology
ISBN:9780815344322
Author:Bruce Alberts, Alexander D. Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter Walter
Publisher:W. W. Norton & Company
Text book image
Laboratory Manual For Human Anatomy & Physiology
Biology
ISBN:9781260159363
Author:Martin, Terry R., Prentice-craver, Cynthia
Publisher:McGraw-Hill Publishing Co.
Text book image
Inquiry Into Life (16th Edition)
Biology
ISBN:9781260231700
Author:Sylvia S. Mader, Michael Windelspecht
Publisher:McGraw Hill Education