Macular degeneration is the most common cause of blindness in people older than 60 years. One variable thought to be related to a type of inflammation associated with this disease is level of a substance called soluble Fas ligand (sFasL) in the blood.
The accompanying table contains representative data on x = sFasL level for 10 patients with age-related macular degeneration. These data are consistent with summary quantities and descriptions of the data given in the paper “Associations of Plasma-Soluble Fas Ligand with Aging and Age-Related Macular Degeneration” (Investigative Ophthalmology & Visual Science [2008]: 1345–1349).
The authors of the paper noted that the distribution of sFasL level was skewed and recommended a cube-root transformation. The cube-root values and the normal scores for a sample size of 10 are also given in the accompanying table.
- a. Construct a normal
probability plot using the untransformed data. - b. Does the normal probability plot for the untransformed data appear linear or curved?
- c. Construct a normal probability plot using the cube-root transformed data. Does the normal probability plot appear more nearly linear than the plot for the untransformed data?
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Chapter 7 Solutions
Introduction To Statistics And Data Analysis
- Left ventricular mass (LVM) is an important risk factor for subsequent cardiovascular disease. A study is proposed to assess the relationship between childhood blood-pressure levels and LVM in children as determined from echocardiograms. The goal is to stratify children into a normal bp group (< 80th percentile for their age, gender, and height) and an elevated bp group (≥ 90th percentile for their age, gender, and height) and compare change in LVM between the two groups. Before this can be done, one needs to demonstrate that LVM actually changes in children over a 4-year period.To help plan the main study, a pilot study is conducted where echocardiograms are obtained from 10 random children from the Bogalusa Heart Study at baseline and after 4 years of follow-up. The data are given in Table 9.18. A)Suppose the investigators are reluctant to assume that the change in LVM over four years is normally distributed. What test can be used to assess if there is a change in mean LVM over…arrow_forwardLeft ventricular mass (LVM) is an important risk factor for subsequent cardiovascular disease. A study is proposed to assess the relationship between childhood blood-pressure levels and LVM in children as determined from echocardiograms. The goal is to stratify children into a normal bp group (< 80th percentile for their age, gender, and height) and an elevated bp group (≥ 90th percentile for their age, gender, and height) and compare change in LVM between the two groups. Before this can be done, one needs to demonstrate that LVM actually changes in children over a 4-year period. To help plan the main study, a pilot study is conducted where echocardiograms are obtained from 10 random children from the Bogalusa Heart Study at baseline and after 4 years of follow-up. The data are given in Table 9.18 (Note: These are the same data as in Table 8.27, p. 329). 9.68 What is the critical region at the 5% level? (i.e., for what values of the test statistic will we reject H0 at the 5% level?)…arrow_forwardLeft ventricular mass (LVM) is an important risk factor for subsequent cardiovascular disease. A study is proposed to assess the relationship between childhood blood-pressure levels and LVM in children as determined from echocardiograms. The goal is to stratify children into a normal bp group (< 80th percentile for their age, gender, and height)and an elevated bp group (≥ 90th percentile for their age, gender, and height) and compare change in LVM between the two groups. Before this can be done, one needs to demonstrate that LVM actually changes in children over a 4-year period. To help plan the main study, a pilot study is conducted where echocardiograms are obtained from 10 random children from the Bogalusa Heart Study at baseline and after4 years of follow-up. The data are given in images. a) Suppose the investigators are reluctant to assume that the change in LVM over four years is normally distributed. What test can be used to assess if there is a change in mean LVM over four…arrow_forward
- Left ventricular mass (LVM) is an important risk factor for subsequent cardiovascular disease. A study is proposed to assess the relationship between childhood blood-pressure levels and LVM in children as determined from echocardiograms. The goal is to stratify children into a normal bp group (< 80th percentile for their age, gender, and height) and an elevated bp group (≥ 90th percentile for their age, gender, and height) and compare change in LVM between the two groups. Before this can be done, one needs to demonstrate that LVM actually changes in children over a 4-year period. To help plan the main study, a pilot study is conducted where echocardiograms are obtained from 10 random children from the Bogalusa Heart Study at baseline and after 4 years of follow-up. The data are given in Table 9.18 (Note: These are the same data as in Table 8.27, p. 329). 9.71 Compare your results in Problems 9.69 and 9.70. 9.72 Compare your results to those obtained using t test methods in Problem…arrow_forwardLeft ventricular mass (LVM) is an important risk factor for subsequent cardiovascular disease. A study is proposed to assess the relationship between childhood blood-pressure levels and LVM in children as determined from echocardiograms. The goal is to stratify children into a normal bp group (< 90th percentile for their age, gender, and height) and an elevated bp group (≥ 90th percentile for their age, gender, and height) and compare change in LVM between the two groups. Before this can be done, one needs to demonstrate that LVM actually changes in children over a 4-year period. To help plan the main study, a pilot study is conducted where echocardiograms are obtained from 10 random children from the Bogalusa Heart Study at baseline and after 4 years of follow-up. The data are given in Table 1 . Table 1 Pilot data on left ventricular mass (LVM) in children from the Bogalusa Heart Study ID Baseline LVM (g) 4- year LVM (g) Change (g)* 1 139 163 24 2 134 126 -8 3 86 142 56…arrow_forwardLeft ventricular mass (LVM) is an important risk factor for subsequent cardiovascular disease. A study is proposed to assess the relationship between childhood blood-pressure levels and LVM in children as determined from echocardiograms. The goal is to stratify children into a normal bp group (< 90th percentile for their age, gender, and height) and an elevated bp group (≥ 90th percentile for their age, gender, and height) and compare change in LVM between the two groups. Before this can be done, one needs to demonstrate that LVM actually changes in children over a 4-year period. To help plan the main study, a pilot study is conducted where echocardiograms are obtained from 10 random children from the Bogalusa Heart Study at baseline and after 4 years of follow-up. The data are given in Table 1 . Table 1 Pilot data on left ventricular mass (LVM) in children from the Bogalusa Heart Study ID Baseline LVM (g) 4- year LVM (g) Change (g)* 1 139 163 24 2 134 126 -8 3 86 142 56…arrow_forward
- The data in the attached image represents blood pressure based on a new trial medication used in an experiment involving a total of 50 male and female subjects. There were two levels of treatment: 0 = placebo and 1 = treatment group. Family History Blood Pressure = Fam-Hist-BP; from the paternal side = PS; from the maternal side = MS; from both sides = BS; none on both sides or not known = N.; Blood pressure before the experiment = BP-Before-Exp; Blood pressure after the experiment = BP-After-Exp. Task: Construct a side-by-side boxplot to compare the variables BP-Before-Exp and BP-After-Exp.arrow_forwardThe data in the attached image represents blood pressure based on a new trial medication used in an experiment involving a total of 50 male and female subjects. There were two levels of treatment: 0 = placebo and 1 = treatment group. Family History Blood Pressure = Fam-Hist-BP; from the paternal side = PS; from the maternal side = MS; from both sides = BS; none on both sides or not known = N.; Blood pressure before the experiment = BP-Before-Exp; Blood pressure after the experiment = BP-After-Exp. Task: Construct a histogram to represent the family BP history, the subjects' BP before treatment and the subjects' BP after treatment.arrow_forwardThe data in the attached image represents blood pressure based on a new trial medication used in an experiment involving a total of 50 male and female subjects. There were two levels of treatment: 0 = placebo and 1 = treatment group. Family History Blood Pressure = Fam-Hist-BP; from the paternal side = PS; from the maternal side = MS; from both sides = BS; none on both sides or not known = N.; Blood pressure before the experiment = BP-Before-Exp; Blood pressure after the experiment = BP-After-Exp. Task: Find the mean and standard deviation for the family history group, the before treatment group, and the after treatment group.arrow_forward
- The data in the attached image represents blood pressure based on a new trial medication used in an experiment involving a total of 50 male and female subjects. There were two levels of treatment: 0 = placebo and 1 = treatment group. Family History Blood Pressure = Fam-Hist-BP; from the paternal side = PS; from the maternal side = MS; from both sides = BS; none on both sides or not known = N.; Blood pressure before the experiment = BP-Before-Exp; Blood pressure after the experiment = BP-After-Exp. Task: Generate at least two different cross tabulations.arrow_forwardAnemia (low healthy blood cells or hemoglobin) has an important role in exercise performance. However, the direct link between rapid changes of hemoglobin and exercise performance is still unknown. A study investigated 18 patients with a blood disorder (beta-thalassemia). Participants in the study performed an exercise test before and the day after receiving a blood transfusion. Data are given in the table. HB = Hemoglobin RER = Respiratory exchange ID Change in HB Obese RER > 1.1 ratio No No 1 -1.4 No -1.5 No Yes No Yes 3 -2 No 4 -2.1 No -1.9 Yes Yes No -1.6 -1.8 -0.8 6 7 No Yes No Yes 8 9. -1 No No -1.2 No Yes 10 11 No No -0.8 -1.5 12 Yes No No Yes 13 14 -1.4 -2.6 -1.7 No No Yes Yes 15 Yes No Yes Yes 16 -2.6 No 17 18 -2.7 -1.5 Noarrow_forwardBlood cocaine concentration (mg/L) was determinedboth for a sample of individuals who had died fromcocaine-induced excited delirium (ED) and for a sampleof those who had died from a cocaine overdose withoutexcited delirium; survival time for people in bothgroups was at most 6 hours. The accompanying datawas read from a comparative boxplot in the article“Fatal Excited Delirium Following Cocaine Use” (J.of Forensic Sciences, 1997: 25–31). ED 0 0 0 0 .1 .1 .1 .1 .2 .2 .3 .3.3 .4 .5 .7 .8 1.0 1.5 2.7 2.83.5 4.0 8.9 9.2 11.7 21.0Non-ED 0 0 0 0 0 .1 .1 .1 .1 .2 .2 .2.3 .3 .3 .4 .5 .5 .6 .8 .9 1.01.2 1.4 1.5 1.7 2.0 3.2 3.5 4.14.3 4.8 5.0 5.6 5.9 6.0 6.4 7.98.3 8.7 9.1 9.6 9.9 11.0 11.512.2 12.7 14.0 16.6 17.8 a. Determine the medians, fourths, and fourth spreadsfor the two samples.b. Are there any outliers in either sample? Any extremeoutliers?c. Construct a comparative boxplot, and use it as abasis for comparing and contrasting the ED andnon-ED samples.arrow_forward
- Glencoe Algebra 1, Student Edition, 9780079039897...AlgebraISBN:9780079039897Author:CarterPublisher:McGraw HillBig Ideas Math A Bridge To Success Algebra 1: Stu...AlgebraISBN:9781680331141Author:HOUGHTON MIFFLIN HARCOURTPublisher:Houghton Mifflin Harcourt