Chapter 7.3, Problem 6ATS

Interpretation Introduction

Interpretation: The synthesis of Aldingenin C involves the conversion of the compound to 2 via the intramolecular ${\text{S}}_{\text{N}}\text{2}$ process. It involves the ring-opening of an epoxide ring with a very poor leaving group. The transition state and leaving group are to be interpreted.

  

Concept introduction:

A molecule can have both nucleophilic and electrophilic centers. An electrophilic center must be electron-deficient and can form a bond with a nucleophile. Here the nucleophile is an electron-rich species that can react with cation or any other electrophile. The ${\text{S}}_{\text{N}}\text{2}$ mechanism involves the loss of leaving group and the attack of nucleophiles in one step with the formation of the transition state.