Biochemistry: Concepts and Connections (2nd Edition)
2nd Edition
ISBN: 9780134641621
Author: Dean R. Appling, Spencer J. Anthony-Cahill, Christopher K. Mathews
Publisher: PEARSON
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Question
Chapter 7, Problem 9P
Interpretation Introduction
Interpretation:
The given hemoglobin mutation are:
- β146(HC3) His → Asp
- β 92(F8) His → Leu
To compare native and mutant hemoglobin that would move faster to the anode. pI of hemoglobin is 7.0 and the electrophoresis is done at pH is 8.0.
Concept Introduction:
pI is also known as the isoeletcric point. It is the pH at which an amino has no net charge. The amino acid exists as a zwitterion at its pI. In a zwitterion the net positive charge is balanced by the net negative charge.
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12. When glutamic acid is heated to 180°C., it loses a molecule of water to form a
lactam. The bond that creates the lactam is an amide bond that forms between the
amino nitrogen and the carbon of the side chain -COOH group. What is the most
reasonable structure for this lactam? (NOTE: The structure of glutamic acid is shown
in Question 1.)
COOH
COOH
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C
D
COOH
B
COOH
E
COOH
10. Which one of the
following compounds is
the major organic product
of the series of reactions
shown here?
Ph
A
OH
Ph
B
CO₂Et
Br
-H
Ν ΚΑ
CO₂Et
1. NaOEt
1. NaOH, H₂O
2. H3O+
2. PhCH2CH2Br
3. heat
NH2
Ph
OH
NH2
0
OH
Ph
OH
NH2
Ph
D
NH2
E
OH
1. What is the isoelectric point of glutamic acid?
(Glutamic acid has pKa1 2.10, pKa2 4.07, pKaз 9.47)
A) pH 2.1
D) pH 6.8
B) pH 3.1
C) pH 4.1
E) pH 9.5
HO
NH2
Glutamic acid
(shown without charges)
OH
Chapter 7 Solutions
Biochemistry: Concepts and Connections (2nd Edition)
Ch. 7 - Prob. 1PCh. 7 - Certain antibodies have been shown to bind only to...Ch. 7 - Antibodies raised against a macromolecular antigen...Ch. 7 - Prob. 4PCh. 7 - Prob. 5PCh. 7 - Prob. 6PCh. 7 - Prob. 7PCh. 7 - Prob. 8PCh. 7 - Prob. 9PCh. 7 - Prob. 10P
Ch. 7 - Prob. 11PCh. 7 - Prob. 12PCh. 7 - Prob. 13PCh. 7 - Suppose your biking partner claims that...Ch. 7 - Prob. 15PCh. 7 - An antibody has been isolated that binds to...Ch. 7 - A typical relaxed sarcomere is about 2.3 m in...Ch. 7 - Each gram of mammalian skeletal muscle consumes...Ch. 7 - A few hours after the death of an animal, the...
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