Biology: Concepts and Investigations
5th Edition
ISBN: 9781260259049
Author: Hoefnagels
Publisher: MCG
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Question
Chapter 6.7, Problem 1MC
Summary Introduction
To determine:
The points at which digested polysaccharides, proteins and fats enter the energy pathways.
Concept introduction:
The large macromolecules like proteins, carbohydrates and fats are broken down into simpler forms to release energy. The simpler molecules are then further broken down to pyruvate or
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Digoxin: Intravenous Bolus - Two Compartment Model
Drug
Digoxin
Route:
IV Bolus
Dose:
0.750 mg
Plasma Concentration Time Profile
Beta
Alpha
Time (hrs)
Conc (ng/ml)
LN
(ng/ml)
LN
(ng/ml)
LN
0.00
#NUM!
#NUM!
#NUM!
0.10
12.290
2.509
#NUM!
#NUMI
0.60
6.975
1.942
#NUM!
#NUMI
1.00
4.649
1.537
#NUM!
#NUMI
2.00
2.201
0.789
#NUM!
#NUM!
3.00
1.536
0.429
#NUM!
#NUM!
4.00
1.342
0.294
#NUM!
#NUM!
5.00
1.273
0.241
#NUM!
#NUMI
6.00
1.238
0.213
#NUM!
#NUM!
7.00
1.212
0.192
#NUM!
#NUM!
8.00
1.188
0.172
#NUMI
#NUM!
9.00
1.165
0.153
#NUM!
#NUMI
10.00
1.143
0.134
#NUMI
#NUM!
11.00
1.122
0.115
#NUM!
12.00
1.101
0.096
#NUMI
13.00
1.080
0.077
#NUMI
16.00
1.020
0.020
#NUMI
24.00
0.876
-0.132
#NUMI
Pharmacokinetic Parameters
Parameter
Value
Alpha
B
Beta
Units
ng/ml
hr-1
ng/ml
hr-1
CO
ng/ml
H.C
AUC
ng x hr/ml
Vc
Vbeta
Vss
C
L/hr
TK (alpha)
hr
TX (beta)
days
5+
F3
F4
F5
0+
F6
F7
%
6
95
14
#3
29
&
t
F8
F9
FW
EW
Linuron, a derivative of urea, is used as an herbicide. Linuron serum levels were measured in 4Kg
rabbits following a bolus IV injection of 10mg/kg.
Time (minutes)
Serum Linuron Levels (ug/ml)
following IV dose
10
15.48
20
8.60
30
5.90
45
3.78
60
2.42
90
1.49
120
0.93
180
0.60
240
0.41
300
0.29
360
0.22
Analyze this data and perform the necessary calculations to determine the following pharmacokinetic
parameters from the IV data: (5 points per parameter, 24 parameters/variables ■ 120 points
possible). You do NOT need to submit graphs or data tables.
Give the terminal regression line equation and R or R² value:
Give the x axis (name and units, if any) of the terminal line:
Give the y axis (name and units, if any) of the terminal line:
Give the residual regression line equation and R or R² value:
Give the x axis (name and units, if any) of the residual line:
Give the y axis (name and units, if any) of the residual line:
Chapter 6 Solutions
Biology: Concepts and Investigations
Ch. 6.1 - Why do all organisms need ATP?Ch. 6.1 - What are the three general ways to generate ATP...Ch. 6.1 - Prob. 3MCCh. 6.1 - Prob. 4MCCh. 6.2 - Prob. 1MCCh. 6.2 - What occurs in each of the three stages of...Ch. 6.3 - Prob. 1MCCh. 6.3 - Prob. 2MCCh. 6.4 - Prob. 1MCCh. 6.4 - Prob. 2MC
Ch. 6.4 - Prob. 3MCCh. 6.5 - Prob. 1MCCh. 6.5 - Prob. 2MCCh. 6.5 - Prob. 3MCCh. 6.5 - Prob. 4MCCh. 6.6 - Prob. 1MCCh. 6.6 - How does the actual ATP yield compare to the...Ch. 6.7 - Prob. 1MCCh. 6.7 - Prob. 2MCCh. 6.8 - Prob. 1MCCh. 6.8 - Prob. 2MCCh. 6.8 - Prob. 3MCCh. 6.9 - Prob. 1MCCh. 6.9 - Why must the first metabolic pathways have been...Ch. 6.9 - What is the evidence that photosynthesis may have...Ch. 6.10 - What hypothesis were the researchers testing, and...Ch. 6.10 - Prob. 2MCCh. 6 - Which of the following best describes aerobic...Ch. 6 - Which stage in cellular respiration produces the...Ch. 6 - What is the role of ATP synthase? a. It uses ATP...Ch. 6 - Prob. 4MCQCh. 6 - Prob. 5MCQCh. 6 - What is endosymbiosis? a. A type of fermentation...Ch. 6 - Respiration contains the Latin word root spiro,...Ch. 6 - All steps of cellular respiration are closely...Ch. 6 - How might a mitochondrion's double membrane make...Ch. 6 - Health-food stores sell a product called pyruvate...Ch. 6 - At what point does O2 enter the energy pathways of...Ch. 6 - Describe the energy pathways that are available...Ch. 6 - Prob. 7WIOCh. 6 - Describe how aerobic respiration occurs in...Ch. 6 - Prob. 9WIOCh. 6 - Explain the fact that species as diverse as humans...Ch. 6 - Prob. 11WIOCh. 6 - Prob. 1PITCh. 6 - Prob. 2PITCh. 6 - Prob. 3PITCh. 6 - Where would fermentation, anaerobic respiration,...
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