Laboratory Manual For Human Anatomy & Physiology
4th Edition
ISBN: 9781260159363
Author: Martin, Terry R., Prentice-craver, Cynthia
Publisher: McGraw-Hill Publishing Co.
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Textbook Question
Chapter 66, Problem 1.5A
What do you think is the function of the transverse ridges in the hard palate of the pig?
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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine:
(a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip
MAKE SURE ANSWERS HAVE UNITS if appropriate.
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2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0
Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present. Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…
The current nutrition labelling regulation in Hong Kong requires food manufacturer to list E+7 information on the package of pre-packaged food products. Do you think that more nutrients, such as calcium and cholesterol, shall be included?
Chapter 66 Solutions
Laboratory Manual For Human Anatomy & Physiology
Ch. 66 - Compare the locations of the major salivary glands...Ch. 66 - Compare the types and numbers of primary...Ch. 66 - In what ways do the pig’s teeth seem to be adapted...Ch. 66 - What part of the human soft palate is lacking in...Ch. 66 - What do you think is the function of the...Ch. 66 - Describe the papillae on the surface of the tongue...Ch. 66 - Describe how the peritoneum and mesenteries are...Ch. 66 - Describe the inner lining of the stomach.Ch. 66 - Compare the structure of the human liver with that...Ch. 66 - Compare the structure and location of the human...
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