The article “Capillary Leak Syndrome in Children with C4A-Deficiency Undergoing Cardiac Surgery with Cardiopulmonary Bypass: A Double-Blind, Randomised Controlled Study” (S. Zhang, S. Wang, et al., Lancet, 2005:556–562) presents the results of a study of the effectiveness of giving blood plasma containing complement component C4A to pediatric cardiopulmonary bypass patients. Of 58 patients receiving C4A-rich plasma, the average length of hospital stay was 8.5 days and the standard deviation was 1.9 days. Of 58 patients receiving C4A-free plasma, the average length of hospital stay was 11.9 days and the standard deviation was 3.6 days. Can you conclude that the
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- A case–control study of patients on antihypertensive drugs related an increased risk of myocardial infarction (MI) for patients using calcium channel blockers (Psaty, et al.,1995). In this study, cases were antihypertensive drug patients who had suffered a first fatal or nonfatal MI through 1993, and controls were antihypertensive patients, matched by demographic factors, who had not suffered a MI. Among the comparisons reported were patients receiving calcium channel (CC) blockers (with and without diuretics) and patients receiving β–blockers (with and without diuretics). Results of numbers of patient by drug/MI status combination are given in Table 1. Compute the odds ratio of suffering MI (CC blockers relative to β–blockers), and the corresponding 95% CI. Does it appear that calcium channel blockers are associated with higher odds (and thus probability) of suffering MI than β –blockers? Table 1: Observed cell counts for antihypertensive drug/MI data Occurrence of…arrow_forwardDexamethasone and IQ. In the paper “Outcomes at School Age After Postnatal Dexamethasone Therapy for Lung Disease of Prematurity” (New England Journal of Medicine, Vol. 350, No. 13, pp. 1304–1313), T. Yeh et al. studied the outcomes at school age in children who had participated in a double-blind, placebo-controlled trial of early postnatal dexamethasone therapy for the prevention of chronic lung disease of prematurity. One result reported in the study was that, at school age, the control group of 74 children had an average IQ score of 84.4, whereas the dexamethasone group of 72 children had an average IQ score of 78. a. experimental units. b. response variable. c. factor(s). d. levels of each factor. e. treatments.arrow_forwardDexamethasone and IQ. In the paper “Outcomes at School Age After Postnatal Dexamethasone Therapy for Lung Disease of Prematurity” (New England Journal of Medicine, Vol. 350, No. 13, pp. 1304–1313), T. Yeh et al. studied the outcomes at school age in children who had participated in a double-blind, placebo-controlled trial of early postnatal dexamethasone therapy for the prevention of chronic lung disease of prematurity. All of the infants in the study had had severe respiratory distress syndrome requiring mechanical ventilation shortly after birth. On the WeissStats site, we provide the school-age IQs of the 74 children in the control group, based on the study results. Use the technology of your choice to do the following. a. Obtain a normal probability plot, boxplot, histogram, and stemand-leaf diagram of the data. b. Based on your results from part (a), can you reasonably apply one-standard-deviation χ2-procedures to the data? Explain your reasoning. c. Overall, IQs of school-age…arrow_forward
- a pathological video game user(PVGU) is à video game user averages 31 or more hours a week of of gameplay.arrow_forwardAn article in the Journal of the American Medical Association documents the results of a randomized clinical trial designed to evaluate whether the influenza vaccine is effective in reducing the occurrence of acute Otitis media (AOM) in young children. Acute otitis media is an infection that causes inflammation of the middle ear canal. In the study, children were randomized to receive either the influenza vaccine or a placebo. The children were followed for one year after randomization, and monitored for AOM during this period. 262 children were randomized to the vaccine group, and 150 of these children experienced at least one incident of AOM during the follow-up period. 134 children were randomized to the placebo group, and 83 of these children experience at least one incident of AOM during the follow-up period. Estimate a 95% confidence interval for the proportion of children experiencing at least one incident of AOM in the group that received the Influenza Vaccine.Estimate a 95%…arrow_forwardAngioplasty is a medical procedure in which an obstructed blood vessel is widened. In some cases, a wire mesh tube, called a stent, is placed in the vessel to help it remain open. The article “Long-term Outcomes of Patients Receiving Drug-eluting Stents” (A. Philpott, D. Southern, et al., Canadian Medical Association Journal, 2009:167–174) presents the results of a study comparing the effectiveness of a bare metal stent with one that that has been coated with a drug designed to prevent reblocking of the vessel. A total of 5320 patients received bare metal stents, and of these, 841 needed treatment for reblocking within a year. A total of 1120 received drug coated stents, and 134 of them required treatment within a year. a) Find a 98% confidence interval for the differences between the proportions for drug coated stents and bare metal stents. b) Suppose that additional patients are to be treated in order to increase the precision of the confidence interval. Three sampling plans are…arrow_forward
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