Seeley's Anatomy & Physiology
11th Edition
ISBN: 9780077736224
Author: Cinnamon VanPutte, Jennifer Regan, Andrew F. Russo Dr., Rod R. Seeley Dr.
Publisher: McGraw-Hill Education
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Chapter 6.4, Problem 16AYP
Where are the periosteum and endosteum located, and what types of cells are found in each? What is the function of perforating (Sharpey) fibers?
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 6 Solutions
Seeley's Anatomy & Physiology
Ch. 6.1 - Name the four components of the skeletal system.Ch. 6.1 - Describe the five major functions of the skeletal...Ch. 6.2 - What are the three types of cartilage? Which type...Ch. 6.2 - Describe the structure of hyaline cartilage. Name...Ch. 6.2 - Differentiate between oppositional and...Ch. 6.3 - Name the components of bone matrix, and explain...Ch. 6.3 - Differentiate among the characteristics and...Ch. 6.3 - Describe the formation of new bone by appositional...Ch. 6.3 - What cells give rise to osteochondral progenitor...Ch. 6.3 - How is the organization of collagen fibers...
Ch. 6.3 - Describe the structure of spongy bone. What are...Ch. 6.3 - Describe the structure of compact bone. What is an...Ch. 6.3 - Trace the pathway nutrients must follow from blood...Ch. 6.4 - List the four basic shapes of bones, and give an...Ch. 6.4 - Sketch and lable the parts of a typical long bone.Ch. 6.4 - Where are the periosteum and endosteum located,...Ch. 6.4 - What are red and yellow bone marrows? Where are...Ch. 6.4 - Compare the structure of a long bone with those of...Ch. 6.5 - Describe the formation of spongy and compact bone...Ch. 6.5 - For the process of endochondral ossification,...Ch. 6.5 - When do primary and secondary Ossification centers...Ch. 6.5 - What bones, or parts of bones, are formed from...Ch. 6.6 - Name and describe the events occurring in the four...Ch. 6.6 - Explain the process of growth at the articular...Ch. 6.6 - Describe how new osteons are produced as a bone...Ch. 6.6 - Prob. 26AYPCh. 6.6 - Prob. 27AYPCh. 6.6 - Prob. 28AYPCh. 6.7 - Why is it important for bone remodeling to occur?Ch. 6.7 - What is a basic multicellular unit (BMU)? Explain...Ch. 6.7 - Prob. 31AYPCh. 6.8 - What are the four steps of bone repair?Ch. 6.8 - Prob. 33AYPCh. 6.8 - Distinguish between the location and composition...Ch. 6.8 - Prob. 35AYPCh. 6.9 - Prob. 36AYPCh. 6.9 - Prob. 37AYPCh. 6.9 - Prob. 38AYPCh. 6.9 - Prob. 39AYPCh. 6.10 - What effect does aging hove on the quality and...Ch. 6.10 - Prob. 41AYPCh. 6 - Prob. 1RACCh. 6 - Chondrocytes are mature cartilage cells within the...Ch. 6 - Which of these statements concerning cartilage is...Ch. 6 - Prob. 4RACCh. 6 - Prob. 5RACCh. 6 - Prob. 6RACCh. 6 - Prob. 7RACCh. 6 - Prob. 8RACCh. 6 - Prob. 9RACCh. 6 - Prob. 10RACCh. 6 - Prob. 11RACCh. 6 - The periosteum a. is an epithelial tissue...Ch. 6 - Prob. 13RACCh. 6 - Prob. 14RACCh. 6 - Prob. 15RACCh. 6 - Prob. 16RACCh. 6 - Prob. 17RACCh. 6 - During growth in length of a long bone, cartilage...Ch. 6 - Prob. 19RACCh. 6 - Prob. 20RACCh. 6 - Prob. 21RACCh. 6 - Bone remodelling can occur When woven bone is...Ch. 6 - Given these processes: (1) cartilage ossification...Ch. 6 - Which of these processes during bone repair...Ch. 6 - Prob. 25RACCh. 6 - Prob. 1CTCh. 6 - Explain why running helps prevent osteoporosis in...Ch. 6 - Prob. 3CTCh. 6 - Prob. 4CTCh. 6 - Prob. 5CTCh. 6 - Prob. 6CT
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- Select a diet and give a summary of the main components. Do a web search of the diet and choose one link that provides misinformation. Explain why the site itself and/or the information on the site is not credible. This should be a report. This site should be different from U.S News and World Report. For full credit, you must include the following information and elaborate in detail: The diet name The main components of the diet The misinformation website and link What misinformation is being provided in the other website and how did you determine it was not credible?arrow_forward1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine: (a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip MAKE SURE ANSWERS HAVE UNITS if appropriate. SHOW ALL WORK, including equation used, variables used and each step to your solution.arrow_forward2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0 Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present. Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…arrow_forward
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