Human Physiology: An Integrated Approach Plus Mastering A&P with Pearson eText -- Access Card Package (8th Edition) (What's New in Human Physiology)
8th Edition
ISBN: 9780134701523
Author: Dee Unglaub Silverthorn
Publisher: PEARSON
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Chapter 6.2, Problem 5CC
Summary Introduction
To name: The three cellular locations of receptors.
Introduction: In the human body, the communication between the cells is essential to transport the information from one cell to another. Cell-to-cell communication is done with the help of a signal transduction pathway.
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 6 Solutions
Human Physiology: An Integrated Approach Plus Mastering A&P with Pearson eText -- Access Card Package (8th Edition) (What's New in Human Physiology)
Ch. 6.1 - Match the communication method on the left with...Ch. 6.1 - Which signal molecules listed in the previous...Ch. 6.1 - A cat sees a mouse and pounces on it. Do you think...Ch. 6.2 - List four components of signal pathways.Ch. 6.2 - Prob. 5CCCh. 6.2 - What are the four steps of signal transduction?Ch. 6.2 - Prob. 7CCCh. 6.2 - Prob. 8CCCh. 6.2 - Name the four categories of membrane receptors.Ch. 6.2 - Prob. 10CC
Ch. 6.2 - Prob. 11CCCh. 6.2 - Prob. 12CCCh. 6.3 - The extracellular fluid Ca2+ concentration...Ch. 6.3 - Prob. 14CCCh. 6.4 - What do receptors, enzymes, and transporters have...Ch. 6.4 - Prob. 16CCCh. 6.4 - Prob. 17CCCh. 6.5 - What is the difference between tonic control and...Ch. 6.5 - Prob. 19CCCh. 6.5 - What is the difference between local control and...Ch. 6.5 - Name the seven steps in a reflex control pathway...Ch. 6.5 - Prob. 22CCCh. 6.5 - Prob. 23CCCh. 6.5 - Prob. 24CCCh. 6 - What are the two routes for long-distance signal...Ch. 6 - Prob. 2RQCh. 6 - Prob. 3RQCh. 6 - Prob. 4RQCh. 6 - Prob. 5RQCh. 6 - An enzyme known as protein kinase adds the...Ch. 6 - Distinguish between central and peripheral...Ch. 6 - Prob. 8RQCh. 6 - Prob. 9RQCh. 6 - Prob. 10RQCh. 6 - Prob. 11RQCh. 6 - Explain the relationships of the terms in each of...Ch. 6 - List and compare the four classes of membrane...Ch. 6 - Prob. 14RQCh. 6 - Prob. 15RQCh. 6 - Prob. 16RQCh. 6 - Prob. 17RQCh. 6 - Identify the target tissue or organ for each...Ch. 6 - Now identify the integrating center for examples...Ch. 6 - In each of the following situations, identify the...Ch. 6 - Prob. 21RQCh. 6 - Prob. 22RQ
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