ANATOMY+PHYSIOLOGY(LL)-W/CONNECT ACCESS
4th Edition
ISBN: 9781266364051
Author: McKinley
Publisher: MCG
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Chapter 6.2, Problem 13WDYL
How does hair function in protection and heat retention?
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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine:
(a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip
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2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0
Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present. Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…
The current nutrition labelling regulation in Hong Kong requires food manufacturer to list E+7 information on the package of pre-packaged food products. Do you think that more nutrients, such as calcium and cholesterol, shall be included?
Chapter 6 Solutions
ANATOMY+PHYSIOLOGY(LL)-W/CONNECT ACCESS
Ch. 6.1 - As you trim your roses, a thorn penetrates your...Ch. 6.1 - Briefly describe the process of keratinization....Ch. 6.1 - Prob. 3WDYLCh. 6.1 - Prob. 4WDYLCh. 6.1 - Compare and contrast the papillary versus...Ch. 6.1 - What is indicated by the lines of cleavage in the...Ch. 6.1 - What types of tissue form the subcutaneous layer?Ch. 6.1 - How does the skin produce vitamin D?Ch. 6.1 - Is the skin entirely waterproof? Explain.Ch. 6.1 - Prob. 10WDYL
Ch. 6.2 - Prob. 11WDYLCh. 6.2 - What are the three zones of a hair?Ch. 6.2 - How does hair function in protection and heat...Ch. 6.2 - Prob. 14WDYLCh. 6.2 - What do sebaceous glands secrete, and where is...Ch. 6.3 - What is granulation tissue, and when does it...Ch. 6.4 - What two primary germ layers form the integument?Ch. 6.4 - How do UV rays contribute to skin aging?Ch. 6 - Prob. 1DYKBCh. 6 - _____ 2. The layer of the epidermis in which cells...Ch. 6 - _____ 3. The sweat glands that communicate with...Ch. 6 - _____ 4. Which of the following is not a function...Ch. 6 - Prob. 5DYKBCh. 6 - Prob. 6DYKBCh. 6 - Prob. 7DYKBCh. 6 - _____ 8. The cells in a hair follicle that are...Ch. 6 - Prob. 9DYKBCh. 6 - Prob. 10DYKBCh. 6 - Describe the composition of the layers of the...Ch. 6 - Prob. 12DYKBCh. 6 - Describe the tissue type and structure of the two...Ch. 6 - Prob. 14DYKBCh. 6 - Compare the structure and composition of the...Ch. 6 - Prob. 16DYKBCh. 6 - Where are ceruminous glands located, and what do...Ch. 6 - Discuss the steps involved in wound repair of the...Ch. 6 - Prob. 19DYKBCh. 6 - Prob. 20DYKBCh. 6 - Prob. 1CALCh. 6 - Prob. 2CALCh. 6 - Prob. 3CALCh. 6 - Prob. 1CSLCh. 6 - Prob. 2CSLCh. 6 - At the age of 50, John noticed that one of the...
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