CAMPBELL BIOLOGY IN FOCUS-W/MASTR.BIO.
3rd Edition
ISBN: 9780134875040
Author: Urry
Publisher: PEARSON
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Textbook Question
Chapter 6.1, Problem 2CC
Describe the forms of energy found in an apple as it grows on a tree, falls, and then is digested by someone who eats it.
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 6 Solutions
CAMPBELL BIOLOGY IN FOCUS-W/MASTR.BIO.
Ch. 6.1 - MAKE CONNECTIONS How does the second law of...Ch. 6.1 - Describe the forms of energy found in an apple as...Ch. 6.2 - Cellular respiration uses glucose and oxygen,...Ch. 6.2 - Prob. 2CCCh. 6.2 - Prob. 3CCCh. 6.3 - How does ATP typically transfer energy from...Ch. 6.3 - Prob. 2CCCh. 6.3 - MAKE CONNECTIONS Does Figure 6.10a show passive or...Ch. 6.4 - Many spontaneous reactions occur very slowly. Why...Ch. 6.4 - Why do enzymes act only on very specific...
Ch. 6.4 - WHAT IF? Malonate is an inhibitor of the enzyme...Ch. 6.4 - A mature lysosome has an internal pH of around...Ch. 6.5 - How do an activator and an inhibitor have...Ch. 6.5 - Prob. 2CCCh. 6 - Choose the pair of terms that correctly completes...Ch. 6 - Prob. 2TYUCh. 6 - Which of the following metabolic processes can...Ch. 6 - If an enzyme in solution is saturated with...Ch. 6 - Some bacteria are metabolically active in hot...Ch. 6 - If an enzyme is added to a solution where its...Ch. 6 - DRAW IT Using a series of arrows, draw the...Ch. 6 - Prob. 8TYUCh. 6 - SCIENCE, TECHNOLOGY, AND SOCIETY Organophosphates...Ch. 6 - FOCUS ON EVOLUTION A recent revival of the...Ch. 6 - FOCUS ON ENERGY AND MATTER Life requires energy....Ch. 6 - SYNTHESIZE YOUR KNOWLEDGE Explain what is...
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