The reason why phenotypic variations due to the inheritance of single allele are very unusual to observe. Introduction: Sex determining factors, which are also called sex chromosomes, are responsible for determining sex in organisms. XX chromosomes in females and XY chromosomes in males are responsible for determining sex. The sex of a child depends upon male as males may transfer either X or Y but female transfers only X. It has been seen that the inheritance of a single allele can cause phenotypic variation, which is very unusual to observe.

Question

You aim to test the hypothesis that the Tbx4 and Tbx5 genes inhibit each other's expression during limb development. With access to chicken embryos and viruses capable of overexpressing Tbx4 and Tbx5, describe an experiment to investigate whether these genes suppress each other's expression in the limb buds. What results would you expect if they do repress each other? What results would you expect if they do not repress each other?

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Question

Chapter 6, Problem 4PDT

Summary Introduction

To determine: The reason why phenotypic variations due to the inheritance of single allele are very unusual to observe.

Introduction: Sex determining factors, which are also called sex chromosomes, are responsible for determining sex in organisms. XX chromosomes in females and XY chromosomes in males are responsible for determining sex. The sex of a child depends upon male as males may transfer either X or Y but female transfers only X. It has been seen that the inheritance of a single allele can cause phenotypic variation, which is very unusual to observe.

Summary Introduction

To determine: The reason why it is difficult to tell at a glance that which allele is present in which organism.

Introduction: Sex determining factors, which are also called sex chromosomes, are responsible for determining sex in organisms. XX chromosomes in females and XY chromosomes in males are responsible for determining sex. The sex of a child depends upon male as males may transfer either X or Y but female transfers only X. It has been seen that the inheritance of single allele can cause phenotypic variation which is very unusual to observe.

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You aim to test the hypothesis that the Tbx4 and Tbx5 genes inhibit each other's expression during limb development. With access to chicken embryos and viruses capable of overexpressing Tbx4 and Tbx5, describe an experiment to investigate whether these genes suppress each other's expression in the limb buds. What results would you expect if they do repress each other? What results would you expect if they do not repress each other?

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You implant an FGF10-coated bead into the anterior flank of a chicken embryo, directly below the level of the wing bud. What is the phenotype of the resulting ectopic limb? Briefly describe the expected expression domains of 1) Shh, 2) Tbx4, and 3) Tbx5 in the resulting ectopic limb bud.