Laboratory Manual for Anatomy and Physiology, 6e Loose-Leaf Print Companion
6th Edition
ISBN: 9781119304142
Author: Connie Allen, Valerie Harper
Publisher: WILEY
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Chapter 6, Problem 2ECTI
Summary Introduction
Introduction: The epithelial cells are usually found on the body surfaces and all the surfaces of the organs like skin, urinary tract, organ surfaces, and in blood vessels. The epithelial cells are one of the primary tissue in the body that take most of the functions in the body system. A simple epithelium can be of three types like simple cuboidal, simple squamous, and simple columnar.
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 6 Solutions
Laboratory Manual for Anatomy and Physiology, 6e Loose-Leaf Print Companion
Ch. 6 - Prob. 1.3BGLCh. 6 - Review the location and function for each...Ch. 6 - Review the location and function for each...Ch. 6 - Review the location and function for each muscle...Ch. 6 - Label and examine the photomicrograph of nervous...Ch. 6 - __________ 1. Cells contain processes that receive...Ch. 6 - __________ 2. Tissue has elongated cells that...Ch. 6 - __________ 3. Tissue contains more extracellular...Ch. 6 - __________ 4. Cells either form a barrier that...Ch. 6 - __________ 5. }Primary tissue types that exhibit...
Ch. 6 - __________ 6. }Primary tissue types that exhibit...Ch. 6 - __________ 7. }Primary tissue types that exhibit...Ch. 6 - __________ 8. }Cells determine function of these...Ch. 6 - __________ 9. }Cells determine function of these...Ch. 6 - __________ 10. }Cells determine function of these...Ch. 6 - __________ 11. The extracellular matrix determines...Ch. 6 - Identify the primary tissue types in Figure...Ch. 6 - Identify the primary tissue types in Figure...Ch. 6 - Identify the primary tissue types in Figure...Ch. 6 - Identify the primary tissue types in Figure...Ch. 6 - ______________________ 1. Lines the mouth and...Ch. 6 - Prob. 2ETCh. 6 - Prob. 3ETCh. 6 - __________ Lines the nasal cavities and moves...Ch. 6 - __________ Forms the mesothelium of the peritoneum...Ch. 6 - __________ Lines the stomach and its microvilli;...Ch. 6 - Prob. 7ETCh. 6 - ______________________ 1. Contains elastic fibers...Ch. 6 - ______________________ 2. Packed with parallel...Ch. 6 - ______________________ 3. Has a firm, gelatinous...Ch. 6 - ______________________ 4. Found under covering and...Ch. 6 - ______________________ 5. Contains many elastic...Ch. 6 - ______________________ 6. Hard extracellular...Ch. 6 - ______________________ 7. Forms a framework in the...Ch. 6 - ______________________ 8. Is packed with bundles...Ch. 6 - ______________________ 9. Fluid extracellular...Ch. 6 - ______________________ 10. Contains a large number...Ch. 6 - ______________________ 11. Hard extracellular...Ch. 6 - Prob. 12CTCh. 6 - ______________________ 13. }Fibroblasts produce...Ch. 6 - ______________________ 14. }Fibroblasts produce...Ch. 6 - ______________________ 15. }Fibroblasts produce...Ch. 6 - ______________________ 16. }Fibroblasts produce...Ch. 6 - ______________________ 17. }Fibroblasts produce...Ch. 6 - ______________________ 18. }Fibroblasts produce...Ch. 6 - ______________________ 19. }Osteoblasts produce...Ch. 6 - ______________________ 20. }Osteoblasts produce...Ch. 6 - ______________________ 21. }Chondroblasts produce...Ch. 6 - ______________________ 22. }Chondroblasts produce...Ch. 6 - ____________________ Chondroblasts produce...Ch. 6 - ______________________ 24. Fibers not present...Ch. 6 - ______________________ 1. Movement of urine...Ch. 6 - _____________________ 2. Movement of bone and/or...Ch. 6 - ______________________ 3. Movement of blood...Ch. 6 - ______________________ 4. Receives and sends...Ch. 6 - ______________________ 5. Movement of food through...Ch. 6 - ______________________ 6. Controls blood flow...Ch. 6 - Identify the epithelia (1 - 6) and connective...Ch. 6 - Identify the epithelia (1 - 6) and connective...Ch. 6 - Identify the epithelia (1 - 6) and connective...Ch. 6 - Identify the epithelia (1 - 6) and connective...Ch. 6 - Identify the epithelia (1 - 6) and connective...Ch. 6 - Identify the epithelia (1 - 6) and connective...Ch. 6 - Identify the epithelia (1 - 6) and connective...Ch. 6 - Identify the epithelia (1 - 6) and connective...Ch. 6 - Identify the epithelia (1 - 6) and connective...Ch. 6 - Identify the epithelia (1 - 6) and connective...Ch. 6 - Identify the epithelia (1 - 6) and connective...Ch. 6 - Identify the epithelia (1 - 6) and connective...Ch. 6 - Identify the epithelia (1 - 6) and connective...Ch. 6 - Identify the epithelia (1 - 6) and connective...Ch. 6 - Identify the epithelia (1 - 6) and connective...Ch. 6 - Identify the epithelia (1 - 6) and connective...Ch. 6 - Identify the epithelia (1 - 6) and connective...Ch. 6 - Identify the epithelia (1 - 6) and connective...Ch. 6 - Identify the muscle tissue types and the nervous...Ch. 6 - Identify the muscle tissue types and the nervous...Ch. 6 - Identify the muscle tissue types and the nervous...Ch. 6 - Identify the muscle tissue types and the nervous...Ch. 6 - Abnormal protein:
Ch. 6 - The effect of the abnormal protein on tissue...Ch. 6 - Prob. 3UYKCh. 6 - The effect of the abnormal protein on tissue...Ch. 6 - Prob. 5UYKCh. 6 - Prob. 6UYKCh. 6 - Prob. 7UYKCh. 6 - Prob. 8UYKCh. 6 - Prob. 9UYKCh. 6 - ureter: ____________________
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