FUNDAMENTALS OF BIOCHEMISTRY - LL FD
5th Edition
ISBN: 9781119598022
Author: Voet
Publisher: WILEY
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Chapter 6, Problem 27CQ
Summary Introduction
To explain: The protein symmetry that consists of 12 identical subunits that are arranged in two stacked rings of six subunits.
Concept introduction: The helical group of identical subunits that has a geometric repetition is called symmetry. The arrangement of protein sequences are analyzed by its symmetry. This plays a significant role for studying the tertiary and quaternary structure of proteins. This helps to understand the function, folding, stability, and evolution of the proteins.
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From the reaction data below, determine whether the reaction is first order or second order and calculate the rate constant.
Time (s)
0
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5.4
1
4.6
2
3.9
3
3.2
4
2.7
5
2.3
Only a plot of In[reactant] versus t gives a straight line, so the reaction is
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Protofilament
20-30 A
Two-chain
Intermediate
flament
-Protob
Protofilament
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0422
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Specific rotation is a measure of a solution's capacity to rotate circularly polarized light. The unfolding of the a helix of a
polypeptide to a random conformation is accompanied by a large decrease in specific rotation.
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pH to 7, there is a large decrease in the specific rotation of the solution. Similarly, polylysine (1.-Lys residues) is an a helix at pH
10, but when researchers lower the pH to 7 the specific rotation also decreases, as shown in the graph.
a Helix
Specific rotation
Poly(Glu)
a Helix
Random
conformation
Poly(Lys)
Random conformation
T
+
°
2
4
6 В
10 12 14
PH
Complete the statements about the molecular mechanism for these changes in specific rotation.
Increasing the pH of a polyglutamate solution from 6 to 7 causes the carboxyl group of each glutamate residue
Comed Artwer
lose a proton. The negatively charged groups in each glutamate residue…
Chapter 6 Solutions
FUNDAMENTALS OF BIOCHEMISTRY - LL FD
Ch. 6 - Prob. 1ECh. 6 - Prob. 2ECh. 6 - 3. Why would you be unlikely to see an ? helix...Ch. 6 - 4. Calculate the length in angstroms of a...Ch. 6 - Prob. 5ECh. 6 - 6. Collagen IV, which occurs in basement...Ch. 6 - 7. Describe the primary, secondary, tertiary, and...Ch. 6 - 8. Explain why gelatin, which is mostly collagen,...Ch. 6 - Prob. 9ECh. 6 - 10. Is it possible for a native protein to be...
Ch. 6 - Prob. 11ECh. 6 - 12. (a) Is Trp or Gln more likely to be on a...Ch. 6 - 13. Classify the following proteins as ?, ?, or...Ch. 6 - 14. Classify the following proteins as ?, ?, or...Ch. 6 - 15. You are performing site-directed mutagenesis...Ch. 6 - 16. Laboratory techniques for randomly linking...Ch. 6 - Prob. 17ECh. 6 - 18. The genetically engineered proteins that...Ch. 6 - Prob. 19ECh. 6 - 20. Experiments in mice suggest that...Ch. 6 - 21. Helices can be described by the notation nm,...Ch. 6 - Prob. 22CQCh. 6 - 23. Which of the following polypeptides is most...Ch. 6 - 24. Which of the peptides in Problem 23 is least...Ch. 6 - Prob. 25CQCh. 6 - 26. What types of rotational symmetry are possible...Ch. 6 - Prob. 27CQCh. 6 - 28. Proteins in solution are often denatured if...Ch. 6 - 29. Given enough time, will all denatured proteins...Ch. 6 - Prob. 30CQCh. 6 - 31. Under physiological conditions, polylysine...Ch. 6 - 32. Would intrinsically disordered polypeptide...Ch. 6 - Prob. 33CQCh. 6 - Prob. 34CQCh. 6 - Prob. 35CQCh. 6 - 36. Not all heat shock proteins are chaperones;...Ch. 6 - 37. Protein denaturation can be triggered by a...Ch. 6 - 38. Explain why ? sheets are less likely to form...Ch. 6 - 39. The GroEL/ES cycle diagrammed in Fig. 6-45...Ch. 6 - Prob. 1MTE
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