Chapter 6, Problem 16P

Answers to all problems are at the end of this book. Detailed solutions are available in the Student Solutions Manual, Study Guide, and Problems Book.

(Research Problem) Conformational Transitions in Proteins How do proteins accomplish conformational changes? How is it that proteins convert precisely and efficiently from one conformation to another'.’ Recall from Figure 6.54 that any folding/unfolding transition must involve movement across a free-energy landscape, and try to imagine the nature of a conformational transition. Are bonds formed and broken along the way'.' What kinds of bonds and interactions might be involved? Suggest how such conformational transitions might occur. One reference that will be useful in this regard is:

Boehr. D.. 2009. During transitions proteins make fleeting bonds. Cell 139: 1049-1051.