Biology
5th Edition
ISBN: 9781260487947
Author: BROOKER
Publisher: MCG
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Chapter 58, Problem 2TY
Summary Introduction
Introduction: An observation was made that 580 species of invertebrates that were bottom-dwelling were found in the lake Baikal in Siberia, which is a very old, temperate and unglaciated lake. An observation was also made that only 4 species of invertebrates that were bottom-dwelling were found in the lake Great Slave, which is a much larger, was glaciated earlier and lies at the same latitude in North Canada.
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Digoxin: Intravenous Bolus - Two Compartment Model
Drug
Digoxin
Route:
IV Bolus
Dose:
0.750 mg
Plasma Concentration Time Profile
Beta
Alpha
Time (hrs)
Conc (ng/ml)
LN
(ng/ml)
LN
(ng/ml)
LN
0.00
#NUM!
#NUM!
#NUM!
0.10
12.290
2.509
#NUM!
#NUMI
0.60
6.975
1.942
#NUM!
#NUMI
1.00
4.649
1.537
#NUM!
#NUMI
2.00
2.201
0.789
#NUM!
#NUM!
3.00
1.536
0.429
#NUM!
#NUM!
4.00
1.342
0.294
#NUM!
#NUM!
5.00
1.273
0.241
#NUM!
#NUMI
6.00
1.238
0.213
#NUM!
#NUM!
7.00
1.212
0.192
#NUM!
#NUM!
8.00
1.188
0.172
#NUMI
#NUM!
9.00
1.165
0.153
#NUM!
#NUMI
10.00
1.143
0.134
#NUMI
#NUM!
11.00
1.122
0.115
#NUM!
12.00
1.101
0.096
#NUMI
13.00
1.080
0.077
#NUMI
16.00
1.020
0.020
#NUMI
24.00
0.876
-0.132
#NUMI
Pharmacokinetic Parameters
Parameter
Value
Alpha
B
Beta
Units
ng/ml
hr-1
ng/ml
hr-1
CO
ng/ml
H.C
AUC
ng x hr/ml
Vc
Vbeta
Vss
C
L/hr
TK (alpha)
hr
TX (beta)
days
5+
F3
F4
F5
0+
F6
F7
%
6
95
14
#3
29
&
t
F8
F9
FW
EW
Linuron, a derivative of urea, is used as an herbicide. Linuron serum levels were measured in 4Kg
rabbits following a bolus IV injection of 10mg/kg.
Time (minutes)
Serum Linuron Levels (ug/ml)
following IV dose
10
15.48
20
8.60
30
5.90
45
3.78
60
2.42
90
1.49
120
0.93
180
0.60
240
0.41
300
0.29
360
0.22
Analyze this data and perform the necessary calculations to determine the following pharmacokinetic
parameters from the IV data: (5 points per parameter, 24 parameters/variables ■ 120 points
possible). You do NOT need to submit graphs or data tables.
Give the terminal regression line equation and R or R² value:
Give the x axis (name and units, if any) of the terminal line:
Give the y axis (name and units, if any) of the terminal line:
Give the residual regression line equation and R or R² value:
Give the x axis (name and units, if any) of the residual line:
Give the y axis (name and units, if any) of the residual line:
Chapter 58 Solutions
Biology
Ch. 58.1 - Prob. 1CCCh. 58.3 - Prob. 1CCCh. 58.3 - Inhibition implies that competition exists between...Ch. 58.4 - Prob. 1CSCh. 58.4 - Prob. 1CCCh. 58.4 - Prob. 1EQCh. 58.4 - Prob. 2EQCh. 58.4 - CoreSKILL What did the researchers conclude about...Ch. 58.5 - Core Skill: Connections In the two food chains...Ch. 58.5 - Prob. 1CC
Ch. 58.5 - Prob. 2CSCh. 58 - Prob. 1TYCh. 58 - Prob. 2TYCh. 58 - Which evidence suggests that more diverse...Ch. 58 - The process of primary succession occurs a. around...Ch. 58 - Prob. 5TYCh. 58 - Prob. 6TYCh. 58 - Prob. 7TYCh. 58 - Prob. 8TYCh. 58 - Prob. 9TYCh. 58 - Prob. 10TYCh. 58 - Prob. 1CQCh. 58 - Prob. 2CQCh. 58 - Core Concept: Systems In the nutrient-poor...Ch. 58 - List some possible ecological disturbances, their...Ch. 58 - Prob. 2COQ
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