Biology
4th Edition
ISBN: 9781259188121
Author: Peter Stiling, Robert Brooker, Linda Graham, Eric Widmaier
Publisher: McGraw-Hill Education
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Chapter 53, Problem 9TY
Summary Introduction
Introduction: The cells that are responsible for adaptive immunity are known as lymphocytes. The body contains two types of lymphocytes: T-cells and B-cells. The B-cells can directly attach to the antigen molecules. However, the T-cells are able to attach only to the antigens that have proteins present on their surface. The proteins that are attached to antigens are called MHC proteins. The MHC proteins are encoded by the genes known as “major histocompatibility complex”. There are two types of MHC proteins: type I and type II MHC proteins.
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Which of the following explains why dendritic cells, but not macrophages or B cells, contribute to the activation of naive T cells?
a. Macrophages and B cells do not express MHC class II molecules until they are activated.
b. Dendritic cells upregulate B7 after engaging innate immunity receptors at sites of infection.
c. Dendritic cells express higher levels of CTLA4.
d. Macrophages and B cells do not process antigen.
e. Dendritic cells use Toll-like receptors to hold antigen in place for extended periods of time.
Which of the following statements about T cells is false? a. Helper T cells release cytokines while cytotoxic T cells kill the infected cell. b. Helper T cells are CD4+, while cytotoxic T cells are CD8+. c. MHC II is a receptor found on most body cells, while MHC I is a receptor found on immune cells only. d. The T cell receptor is found on both CD4+ and CD8+ T cells.
Which of the following statements regarding CD4 is incorrect?
a. MHC class II molecules present antigens to CD4 T cells.
b. CD4 is the receptor used for HIV entry into CD4 T cells.
c. CD4 is made up of two separate membrane-bound chains.
d. Late in the progression of an HIV infection, the number of CD4 T cells in the circulation diminishes.
e. CD4 is referred to as a T-cell co-receptor.
Chapter 53 Solutions
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- Which of the following statements regarding T cells activated by specific antigen is incorrect? a. They receive co-stimulatory signals through CD28. b. They suppress expression of sphingosine 1-phosphate (SIP). c. They take several days before differentiating into effector T cells. d. They cease to secrete and respond to interleukin-2 (IL-2). e. They begin to express CTLA4, which serves to limit T-cell proliferation.arrow_forwardWhich of the following best describes the movement of a T cell through a lymph node? a. It enters via efferent lymphatics and exits via the bloodstream. b. It enters via afferent lymphatics and exits via the bloodstream. c. It enters via the bloodstream and exits via afferent lymphatics. d. It enters via the bloodstream and exits via the bloodstream. e. It enters via the bloodstream and exits via efferent lymphatics.arrow_forwardUnlike naive T lymphocytes, Select one: a. memory T lymphocytes obtain energy from glycolysis. b. memory T lymphocyte populations may include TH1 or TH2 T cells. c. effector T cells do not undergo mitosis when stimulated by antigen. d. effector T cells do not express mTORc1. e. effector T cells undergo high rates of autophagy.arrow_forward
- Which of the following is part of the second line of defense against pathogens?a. skin b. mucus membranesc. lysozyme in tears d. phagocytes Which of the following does NOT have MHC class II molecules on the surface of their cell membranes? a. Macrophages.b. Dendritic cells.c. B cells.d. Helper T cells.arrow_forwardWhich of the following statements are true for antigen presentation. a. Antigen presentation means that other cells attach the pathogen first and present it to T cells. b. Antigen-presenting cells display protein fragments, resulting from the digestion of the pathogen, in complex with MHC receptor to B cells c. Antigen presenting cells display protein fragments, resulting from the digestion of the pathogen, in complex with MHC receptor on their surface. d. Antigen-presenting cells are phagocytic cells e. Antigen presentation is required for T cell activation f. Cytokines released by macrophages are required for T cell activation g. T cell receptors recognize the MHC receptors in complex with antigen fragments displayed by antigen-presenting cells. h. Phagocytic cells are involved in innate immunity. Therefore they have no role in T-cell activationarrow_forwardWhich of the following pairs is mismatched? a. plasma cell: mediation of phagocytosis and killing of microorganisms in the plasma b. megakaryocyte: formation of platelets c. dendritic cell: activation of adaptive immune responses d. natural killer cell: develops from a common lymphoid progenitor e. neutrophil: formation of pus f. regulatory T cell: inhibition of T-cell activity.arrow_forward
- Dendritic cells take up, process or present antigen by all of the following routes except Select one: a. receptor-mediated endocytosis of bacteria. b. macropinocytosis of bacteria or viruses. c. uptake of viruses using Toll-like receptor TLR9. d. cross-presentation from the MHC class II pathway to the MHC class I pathway. Oe. cross-presentation from incoming infected dendritic cells to healthy resident dendritic cells in secondary lymphoid tissue. Of. delivery of viral peptides from cytosol to endoplasmic reticulum during viral infection.arrow_forwardAn MHC class II/antigen complex on the surface of an antigen-presenting cell (APC) binds to a T-cell receptor. What results from this interaction? Select one: a. Other immune cells are stimulated to respond to the antigen. b. Other immune cells are inhibited. c. The T cell responds by directly destroying the APC. d. The antigen is phagocytized by the T cell.arrow_forwardIn regard to antigen presentation, MHC class I molecules usually present peptides derived from _____, whereas MHC class II molecules usually present peptides derived from _____. a. intracellular cytosolic sources; vesicular system b. phagolysosome; proteasomes c. MIIC; self proteins d. CLIP; HLA-DM e. endocytic vesicles; endoplasmic reticulum.arrow_forward
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