Anatomy & Physiology: An Integrative Approach
2nd Edition
ISBN: 9780078024283
Author: Michael McKinley Dr., Valerie O'Loughlin, Theresa Bidle
Publisher: McGraw-Hill Education
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Chapter 5.2, Problem 8WDYL
What are the basic functional differences between resident cells and wandering cells in connective tissue?
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 5 Solutions
Anatomy & Physiology: An Integrative Approach
Ch. 5.1 - Why does an epithelium need to be highly...Ch. 5.1 - Why is an epithelium considered selectively...Ch. 5.1 - How does simple epithelium differ from stratified...Ch. 5.1 - What epithelial tissue lines the air sacs of the...Ch. 5.1 - What epithelial tissue contains multiple layers of...Ch. 5.1 - What are the two basic parts of a multicellular...Ch. 5.1 - What are the differences between holocrine and...Ch. 5.2 - What are the basic functional differences between...Ch. 5.2 - Prob. 9WDYLCh. 5.2 - In what ways does connective tissue provide a...
Ch. 5.2 - Prob. 11WDYLCh. 5.2 - Compare loose connective tissue to dense...Ch. 5.2 - Describe the composition and location of...Ch. 5.2 - Why is blood considered a connective tissue?Ch. 5.3 - Compare and contrast the structure of skeletal and...Ch. 5.4 - What is the difference between a neuron and a...Ch. 5.5 - Prob. 17WDYLCh. 5.5 - What are the differences between the parietal and...Ch. 5.6 - What are the three primary germ layers, and when...Ch. 5.6 - What is the difference between metaplasia,...Ch. 5.6 - How do epithelia and connective tissue change when...Ch. 5 - ____ 1. Which tissue contains a calcified ground...Ch. 5 - ____ 2. Which of the following is not a...Ch. 5 - ____ 3. __________ membranes line body cavities...Ch. 5 - ____ 4. Which of the following is a correct...Ch. 5 - ____ 5. All of the following are characteristics...Ch. 5 - Prob. 6DYKBCh. 5 - ____ 7. Which tissue type is formed from mesoderm?...Ch. 5 - ____ 8. Which muscle type consists of long,...Ch. 5 - ____ 9. Which epithelial tissue type lines the...Ch. 5 - ____ 10. A gland that releases its secretion by...Ch. 5 - What are some characteristics of all types of...Ch. 5 - Describe the two main criteria by which epithelia...Ch. 5 - List the epithelia type that lines (a) the lumen...Ch. 5 - Prob. 14DYKBCh. 5 - Name the four types of body membranes, and cite a...Ch. 5 - What characteristics are common to all connective...Ch. 5 - What are the main structural differences between...Ch. 5 - In what regions of the body would you expect to...Ch. 5 - What are the similarities and differences between...Ch. 5 - What is the difference between neurons and glial...Ch. 5 - John is a 53-year-old construction worker who has...Ch. 5 - Your optometrist shines a light in your eye and...Ch. 5 - During a biology lab, Erin used a cotton swab to...Ch. 5 - During a biology lab, Erin used a cotton swab to...Ch. 5 - During a biology lab, Erin used a cotton swab to...Ch. 5 - During a microscopy exercise in the anatomy...Ch. 5 - Your father is suffering from a painful knee...
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- Select a diet and give a summary of the main components. Do a web search of the diet and choose one link that provides misinformation. Explain why the site itself and/or the information on the site is not credible. This should be a report. This site should be different from U.S News and World Report. For full credit, you must include the following information and elaborate in detail: The diet name The main components of the diet The misinformation website and link What misinformation is being provided in the other website and how did you determine it was not credible?arrow_forward1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine: (a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip MAKE SURE ANSWERS HAVE UNITS if appropriate. SHOW ALL WORK, including equation used, variables used and each step to your solution.arrow_forward2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0 Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present. Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…arrow_forward
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