1 SEM ACCESS W/MCKINLEY TEXT PAC
3rd Edition
ISBN: 9781265485641
Author: McKinley
Publisher: MCG CUSTOM
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Chapter 5.2, Problem 11LO
Summary Introduction
To identify: Three types of molecules that may be found in the ground substances.
Concept introduction: The connective tissues are one of the most diverse and abundant types of tissue in the body. It consists of cells and extracellular matrices that function to support, protect, and bind organs. The connective tissue consists of three components, namely fibers, ground substances, and cells.
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 5 Solutions
1 SEM ACCESS W/MCKINLEY TEXT PAC
Ch. 5.1 - LEARNING OBJECTIVE
1. Describe the common...Ch. 5.1 - Why does an epithelium need to be highly...Ch. 5.1 - Prob. 2LOCh. 5.1 - Prob. 1WDTCh. 5.1 - Why is an epithelium considered selectively...Ch. 5.1 - Prob. 3LOCh. 5.1 - LEARNING OBJECTIVES
4. Give examples of each type...Ch. 5.1 - WHAT DO YOU THINK?
2 Which types of epithelia are...Ch. 5.1 - How does simple epithelium differ from stratified...Ch. 5.1 - What epithelial tissue lines the air sacs of the...
Ch. 5.1 - What epithelial tissue contains multiple layers of...Ch. 5.1 - LEARNING OBJECTIVES
5. Define glands.
Ch. 5.1 - Prob. 6LOCh. 5.1 - Prob. 7LOCh. 5.1 - What are the two basic parts of a multicellular...Ch. 5.1 - What are the differences between holocrine and...Ch. 5.2 - Prob. 8LOCh. 5.2 - Prob. 9LOCh. 5.2 - Prob. 10LOCh. 5.2 - Prob. 11LOCh. 5.2 - What are the basic functional differences between...Ch. 5.2 - Prob. 9WDLCh. 5.2 - Prob. 12LOCh. 5.2 - Prob. 10WDLCh. 5.2 - Prob. 13LOCh. 5.2 - Prob. 11WDLCh. 5.2 - Prob. 14LOCh. 5.2 - Prob. 3WDTCh. 5.2 - Compare loose connective tissue to dense...Ch. 5.2 - Describe the composition and location of...Ch. 5.2 - Why is blood considered a connective tissue?Ch. 5.3 - Prob. 15LOCh. 5.3 - LEARNING OBJECTIVES
16. Compare the functions of...Ch. 5.3 - Prob. 4WDTCh. 5.3 - Compare and contrast the structure of skeletal and...Ch. 5.4 - Prob. 17LOCh. 5.4 - Prob. 18LOCh. 5.4 - What is the difference between a neuron and a...Ch. 5.5 - Prob. 19LOCh. 5.5 - Prob. 20LOCh. 5.5 - Prob. 17WDLCh. 5.5 - LEARNING OBJECTIVE
21. Explain the structure and...Ch. 5.5 - LEARNING OBJECTIVE
22. Identify the locations of...Ch. 5.5 - What are the differences between the parietal and...Ch. 5.6 - Prob. 23LOCh. 5.6 - Prob. 24LOCh. 5.6 - What are the three primary germ layers, and when...Ch. 5.6 - Prob. 25LOCh. 5.6 - What is the difference between metaplasia,...Ch. 5.6 - Prob. 26LOCh. 5.6 - How do epithelia and connective tissue change when...Ch. 5 - ____ 1. Which tissue contains a calcified ground...Ch. 5 - ____ 2. Which of the following is not a...Ch. 5 - ____ 3. __________ membranes line body cavities...Ch. 5 - Do You Know the Basics?
4. Which of the...Ch. 5 - ____ 5. All of the following are characteristics...Ch. 5 - Do You Know the Basics?
6. Which connective...Ch. 5 - ____ 7. Which tissue type is formed from mesoderm?...Ch. 5 - ____ 8. Which muscle type consists of long,...Ch. 5 - ____ 9. Which epithelial tissue type lines the...Ch. 5 - ____ 10. A gland that releases its secretion by...Ch. 5 - What are some characteristics of all types of...Ch. 5 - Describe the two main criteria by which epithelia...Ch. 5 - List the epithelia type that lines (a) the lumen...Ch. 5 - Prob. 14DYBCh. 5 - Name the four types of body membranes, and cite a...Ch. 5 - What characteristics are common to all connective...Ch. 5 - What are the main structural differences between...Ch. 5 - In what regions of the body would you expect to...Ch. 5 - What are the similarities and differences between...Ch. 5 - What is the difference between neurons and glial...Ch. 5 - John is a 53-year-old construction worker who has...Ch. 5 - Your optometrist shines a light in your eye and...Ch. 5 - During a biology lab, Erin used a cotton swab to...Ch. 5 - During a biology lab, Erin used a cotton swab to...Ch. 5 - During a biology lab, Erin used a cotton swab to...Ch. 5 - During a microscopy exercise in the anatomy...Ch. 5 - Your father is suffering from a painful knee...
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