SEELEY'S ANATOMY+PHYSIOLOGY
12th Edition
ISBN: 9781260172195
Author: VanPutte
Publisher: RENT MCG
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Textbook Question
Chapter 5.2, Problem 10AYP
What are cleavage lines, and how are they related to the heading of a cut?
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Digoxin: Intravenous Bolus - Two Compartment Model
Drug
Digoxin
Route:
IV Bolus
Dose:
0.750 mg
Plasma Concentration Time Profile
Beta
Alpha
Time (hrs)
Conc (ng/ml)
LN
(ng/ml)
LN
(ng/ml)
LN
0.00
#NUM!
#NUM!
#NUM!
0.10
12.290
2.509
#NUM!
#NUMI
0.60
6.975
1.942
#NUM!
#NUMI
1.00
4.649
1.537
#NUM!
#NUMI
2.00
2.201
0.789
#NUM!
#NUM!
3.00
1.536
0.429
#NUM!
#NUM!
4.00
1.342
0.294
#NUM!
#NUM!
5.00
1.273
0.241
#NUM!
#NUMI
6.00
1.238
0.213
#NUM!
#NUM!
7.00
1.212
0.192
#NUM!
#NUM!
8.00
1.188
0.172
#NUMI
#NUM!
9.00
1.165
0.153
#NUM!
#NUMI
10.00
1.143
0.134
#NUMI
#NUM!
11.00
1.122
0.115
#NUM!
12.00
1.101
0.096
#NUMI
13.00
1.080
0.077
#NUMI
16.00
1.020
0.020
#NUMI
24.00
0.876
-0.132
#NUMI
Pharmacokinetic Parameters
Parameter
Value
Alpha
B
Beta
Units
ng/ml
hr-1
ng/ml
hr-1
CO
ng/ml
H.C
AUC
ng x hr/ml
Vc
Vbeta
Vss
C
L/hr
TK (alpha)
hr
TX (beta)
days
5+
F3
F4
F5
0+
F6
F7
%
6
95
14
#3
29
&
t
F8
F9
FW
EW
Linuron, a derivative of urea, is used as an herbicide. Linuron serum levels were measured in 4Kg
rabbits following a bolus IV injection of 10mg/kg.
Time (minutes)
Serum Linuron Levels (ug/ml)
following IV dose
10
15.48
20
8.60
30
5.90
45
3.78
60
2.42
90
1.49
120
0.93
180
0.60
240
0.41
300
0.29
360
0.22
Analyze this data and perform the necessary calculations to determine the following pharmacokinetic
parameters from the IV data: (5 points per parameter, 24 parameters/variables ■ 120 points
possible). You do NOT need to submit graphs or data tables.
Give the terminal regression line equation and R or R² value:
Give the x axis (name and units, if any) of the terminal line:
Give the y axis (name and units, if any) of the terminal line:
Give the residual regression line equation and R or R² value:
Give the x axis (name and units, if any) of the residual line:
Give the y axis (name and units, if any) of the residual line:
Chapter 5 Solutions
SEELEY'S ANATOMY+PHYSIOLOGY
Ch. 5.1 - Provide on example for each function of the...Ch. 5.2 - From deepest to most superficial, name and...Ch. 5.2 - Prob. 3AYPCh. 5.2 - Prob. 4AYPCh. 5.2 - Prob. 5AYPCh. 5.2 - How do gentic factors, exposure to sunlight, and...Ch. 5.2 - How do carotene, blood flow, oxygen content, and...Ch. 5.2 - Prob. 8AYPCh. 5.2 - Prob. 9AYPCh. 5.2 - What are cleavage lines, and how are they related...
Ch. 5.3 - Name the types of tissue forming the subcutaneous...Ch. 5.3 - Prob. 12AYPCh. 5.3 - Prob. 13AYPCh. 5.4 - When and where are Ianugo, vellus, and found in...Ch. 5.4 - Prob. 15AYPCh. 5.4 - Prob. 16AYPCh. 5.4 - Describe the ports of a hair follicle. How the...Ch. 5.4 - Prob. 18AYPCh. 5.4 - Prob. 19AYPCh. 5.4 - Prob. 20AYPCh. 5.4 - Prob. 21AYPCh. 5.4 - Which glands of the skin are responsible for...Ch. 5.4 - Name the ports of a nail. Which Port produces most...Ch. 5.4 - Prob. 24AYPCh. 5.5 - In what ways does the skin provide protection?Ch. 5.5 - Prob. 26AYPCh. 5.5 - Prob. 27AYPCh. 5.5 - Prob. 28AYPCh. 5.5 - Prob. 29AYPCh. 5.6 - Prob. 30AYPCh. 5.7 - Compared with young skin, why is aged skin more...Ch. 5.7 - Prob. 32AYPCh. 5.7 - Prob. 33AYPCh. 5.7 - Prob. 34AYPCh. 5 - If a splinter penetrates the skin of the palm of...Ch. 5 - Prob. 2RACCh. 5 - Prob. 3RACCh. 5 - Prob. 4RACCh. 5 - Prob. 5RACCh. 5 - Prob. 6RACCh. 5 - Prob. 7RACCh. 5 - Prob. 8RACCh. 5 - Prob. 9RACCh. 5 - Prob. 10RACCh. 5 - Prob. 11RACCh. 5 - Prob. 12RACCh. 5 - Prob. 13RACCh. 5 - Prob. 14RACCh. 5 - Prob. 15RACCh. 5 - Smooth muscles that are attached to hair follicles...Ch. 5 - Prob. 17RACCh. 5 - For questions 17-19, match the type of gland with...Ch. 5 - Prob. 19RACCh. 5 - Prob. 20RACCh. 5 - Prob. 21RACCh. 5 - Prob. 22RACCh. 5 - Which of these processes increase (s) heat loss...Ch. 5 - Prob. 24RACCh. 5 - The skin of infants is more easily penetrated and...Ch. 5 - Melanocytes are found primarily in the stratum...Ch. 5 - The rare of water loss from the skin of a hand was...Ch. 5 - It has been several weeks since George has...Ch. 5 - Prob. 5CTCh. 5 - Why are your eyelshes not a foot long? Your...Ch. 5 - Pulling on hair can be quite painful, hyet cutting...Ch. 5 - A patient has an ingrown toenail, in which the...Ch. 5 - Defend or refute the following statement:...Ch. 5 - Harry, age 55, went to a health fair and had a PSA...
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