Biological Science
Biological Science
5th Edition
ISBN: 9780321743671
Author: Scott Freeman
Publisher: PEARSON
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Chapter 50, Problem 16TYPSS
Summary Introduction

Introduction:

The BMI (body mass index – standard deviation) is the measure for the weight and sex of a child. BMI is calculated by dividing body mass (in kilograms) with height (in meters) squared. Each age group has an adjusted and predefined BMI z-score value, which shows the physical well-being of a child. Given below are the values representing three age groups with different BMI z-score values before puberty and after puberty.

Biological Science, Chapter 50, Problem 16TYPSS

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You aim to test the hypothesis that the Tbx4 and Tbx5 genes inhibit each other's expression during limb development. With access to chicken embryos and viruses capable of overexpressing Tbx4 and Tbx5, describe an experiment to investigate whether these genes suppress each other's expression in the limb buds. What results would you expect if they do repress each other? What results would you expect if they do not repress each other?
You decide to delete Fgf4 and Fgf8 specifically in the limb bud. Explain why you would not knock out these genes in the entire embryo instead.
You implant an FGF10-coated bead into the anterior flank of a chicken embryo, directly below the level of the wing bud. What is the phenotype of the resulting ectopic limb?  Briefly describe the expected expression domains of 1) Shh, 2) Tbx4, and 3) Tbx5 in the resulting ectopic limb bud.
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