Lehninger Principles Of Biochemistry 7e & Study Guide And Solutions Manual For Lehninger Principles Of Biochemistry 7e
Lehninger Principles Of Biochemistry 7e & Study Guide And Solutions Manual For Lehninger Principles Of Biochemistry 7e
7th Edition
ISBN: 9781319125776
Author: David L. Nelson, Michael M. Cox
Publisher: W. H. Freeman
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Chapter 5, Problem 8P

(a)

Summary Introduction

To determine: Whether HbA or HbF hemoglobin has a higher affinity for oxygen under physiological conditions.

Introduction:

Hemoglobin is the blood protein that carries the oxygen molecule. It is composed of four heme groups which surround the globin group. Heme groups possess iron and provides a red color to the blood cells. Hemoglobin is present in the tetrameric form that consist 2 dimers (α,ß dimmers) that binds to the oxygen molecule. The affinity of oxygen to bind with hemoglobin is isolated from the red blood cells that displays a sigmoidal curve. 2,3- bisphosphoglycerate is a glycolytic intermediate that has an immense affinity for the deoxyhemoglobin molecule.

(b)

Summary Introduction

To determine: The physiological significance of the different O2 affinities.

Introduction:

Hemoglobin is the blood protein that carries the oxygen molecule. It is composed of four heme groups which surround the globin group. Heme groups possess iron and provides a red color to the blood cells. Hemoglobin is present in the tetrameric form that consist 2 dimers (α, ß dimmers) that binds to the oxygen molecule. The affinity of oxygen to bind with hemoglobin is isolated from the red blood cells that displays a sigmoidal curve. 2,3- bisphosphoglycerate is a glycolytic intermediate that has an immense affinity for the deoxyhemoglobin molecule.

(c)

Summary Introduction

To determine: The effect of BPG on the oxygen affinity of hemoglobin and explain the different oxygen affinities of fetal and maternal hemoglobin.

Introduction:

Hemoglobin is the blood protein that carries the oxygen molecule. It is composed of four heme groups which surround the globin group. Heme groups possess iron and provides a red color to the blood cells. Hemoglobin is present in the tetrameric form that consist 2 dimers (α,ß dimmers) that binds to the oxygen molecule. The affinity of oxygen to bind with hemoglobin is isolated from the red blood cells that displays a sigmoidal curve. 2,3- bisphosphoglycerate is a glycolytic intermediate that has an immense affinity for the deoxyhemoglobin molecule.

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