Human Anatomy & Physiology, Books a la Carte Edition (2nd Edition)
2nd Edition
ISBN: 9780134754239
Author: Erin C. Amerman
Publisher: PEARSON
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Textbook Question
Chapter 5, Problem 7CYR
Mark the following statements as true or false. If a statement is false, correct it to make a true statement.
a. Melanocytes account for the bulk of the epidermis.
b. Keratinocytes begin life in the stratum corneum and gradually are pushed into the stratum basale.
c. Dendritic cells are phagocytes of the immune system that protect the skin and deeper tissues from invasion by pathogens.
d. Merkel cells produce the pigment melanin.
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 5 Solutions
Human Anatomy & Physiology, Books a la Carte Edition (2nd Edition)
Ch. 5.1 - 1. What are the major structures of the skin, and...Ch. 5.1 - 2. How does the integument provide protection...Ch. 5.1 - Prob. 3QCCh. 5.1 - What are the other functions of the integument?...Ch. 5.2 - 1. What are the five strata of the epidermis? How...Ch. 5.2 - How does a keratinocyte that begins its life in...Ch. 5.2 - Prob. 3QCCh. 5.2 - Prob. 4QCCh. 5.3 - Which type of tissue makes up the papillary layer...Ch. 5.3 - What are the functions of the dermal papillae?
Ch. 5.3 - 3. Which type of tissue makes up the reticular...Ch. 5.3 - 4. What other structures are located in the...Ch. 5.3 - 5. How does the papillary layer of the dermis...Ch. 5.3 - What causes tension lines and flexure lines? How...Ch. 5.4 - How is melanin produced, and how does it interact...Ch. 5.4 - What are the functions of melanin?Ch. 5.4 - 3. What is carotene, and what color does it give...Ch. 5.4 - Prob. 4QCCh. 5.4 - 5. How can the oxygen content of the blood affect...Ch. 5.4 - 6. What is cyanosis, and what can it tell us...Ch. 5.5 - How do the hair shaft and hair root differ?Ch. 5.5 - How does a hair grow in length?Ch. 5.5 - Prob. 3QCCh. 5.5 - Define the following terms: nail bed, nail plate,...Ch. 5.5 - How does nail growth occur?Ch. 5.5 - Prob. 6QCCh. 5.5 - What are the other three types of sweat glands,...Ch. 5.5 - 8. How do sebaceous glands and sebum differ from...Ch. 5.6 - Prob. 1QCCh. 5.6 - Prob. 2QCCh. 5.6 - What is cancer?Ch. 5.6 - 4. How do the three types of skin cancer differ?
Ch. 5 - Explain why the skin is an organ.Ch. 5 - Which of the following correctly describes the...Ch. 5 - Which of the following is not a function of the...Ch. 5 - 4. Explain what happens to dermal blood vessels...Ch. 5 - Number the strata of thick skin epidermis from...Ch. 5 - Keratinocytes in the superficial strata of the...Ch. 5 - Mark the following statements as true or false. If...Ch. 5 - Which of the following statements is false? a....Ch. 5 - What are the functions of the dermal papillae?Ch. 5 - Epidermal ridges are created by: a. the epidermal...Ch. 5 - 11. Mark the following statements as true or...Ch. 5 - 12. Which of the following is not a function of...Ch. 5 - 13. Fill in the blanks: The portion of the hair...Ch. 5 - Nail growth occurs when: a. cells in the nail...Ch. 5 - Prob. 15CYRCh. 5 - Match each type of gland with its correct...Ch. 5 - How do sweat and sebum differ?Ch. 5 - 18. Which type of burn involves the epidermis and...Ch. 5 - 19. The type of skin tumor that involves the...Ch. 5 - Prob. 1CYUCh. 5 - Prob. 2CYUCh. 5 - The hair and nails are sometimes called accessory...Ch. 5 - 1. You are working in the emergency department...Ch. 5 - 2. After Ramon’s skin came into contact with a...Ch. 5 - 3. Which of the following is not a function of...Ch. 5 - 4. What would happen to the skin if the oil...Ch. 5 - Many antiaging skin creams contain collagen and...Ch. 5 - 6. Would a mild second-degree burn be likely to...
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