Human Anatomy & Physiology, Books a la Carte Edition (2nd Edition)
2nd Edition
ISBN: 9780134754239
Author: Erin C. Amerman
Publisher: PEARSON
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Chapter 5.6, Problem 3QC
What is cancer?
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. Consider a base substitution mutation that occurred in a DNA sequence that resulted in a change in the
encoded protein from the amino acid glutamic acid to aspartic acid. Normally the glutamic acid amino acid
is located on the outside of the soluble protein but not near an active site.
O-H¨
A. What type of mutation occurred?
O-H
B. What 2 types of chemical bonds are found in the R-groups
of each amino acid? The R groups are shaded.
CH2
CH2
CH2
H2N-C-COOH
H2N-C-COOH
1
H
Glutamic acid
H
Aspartic acid
C. What 2 types of bonds could each R-group of each of these amino acids form with other molecules?
D. Consider the chemical properties of the two amino acids and the location of the amino acid in the
protein. Explain what effect this mutation will have on this protein's function and why.
engineered constructs that consist of hollow fibers are acting as synthetic capillaries, around which cells have been loaded. The cellular space around a single fiber can be modeled as if it were a Krogh tissue cylinder. Each fiber has an outside “capillary” radius of 100 µm and the “tissue” radius can be taken as 200 µm. The following values apply to the device:R0 = 20 µM/secaO2 = 1.35 µM/mmHgDO2,T = 1.67 x 10-5 cm2/secPO2,m = 4 x 10-3 cm/secInstead of blood inside the fibers, the oxygen transport and tissue consumption are being investigated by usingan aqueous solution saturated with pure oxygen. As a result, there is no mass transfer resistance in the synthetic“capillary”, only that due to the membrane itself. Rather than accounting for pO2 variations along the length ofthe fiber, use an average value in the “capillary” of 130 mmHg.Is the tissue fully oxygenated?
Molecular Biology
Please help with question. thank you
You are studying the expression of the lac operon. You have isolated mutants as described below. In the presence of glucose, explain/describe what would happen, for each mutant, to the expression of the lac operon when you add lactose AND what would happen when the bacteria has used up all of the lactose (if the mutant is able to use lactose).5. Mutations in the lac operator that strengthen the binding of the lac repressor 200 fold
6. Mutations in the promoter that prevent binding of RNA polymerase
7. Mutations in CRP/CAP protein that prevent binding of cAMP8. Mutations in sigma factor that prevent binding of sigma to core RNA polymerase
Chapter 5 Solutions
Human Anatomy & Physiology, Books a la Carte Edition (2nd Edition)
Ch. 5.1 - 1. What are the major structures of the skin, and...Ch. 5.1 - 2. How does the integument provide protection...Ch. 5.1 - Prob. 3QCCh. 5.1 - What are the other functions of the integument?...Ch. 5.2 - 1. What are the five strata of the epidermis? How...Ch. 5.2 - How does a keratinocyte that begins its life in...Ch. 5.2 - Prob. 3QCCh. 5.2 - Prob. 4QCCh. 5.3 - Which type of tissue makes up the papillary layer...Ch. 5.3 - What are the functions of the dermal papillae?
Ch. 5.3 - 3. Which type of tissue makes up the reticular...Ch. 5.3 - 4. What other structures are located in the...Ch. 5.3 - 5. How does the papillary layer of the dermis...Ch. 5.3 - What causes tension lines and flexure lines? How...Ch. 5.4 - How is melanin produced, and how does it interact...Ch. 5.4 - What are the functions of melanin?Ch. 5.4 - 3. What is carotene, and what color does it give...Ch. 5.4 - Prob. 4QCCh. 5.4 - 5. How can the oxygen content of the blood affect...Ch. 5.4 - 6. What is cyanosis, and what can it tell us...Ch. 5.5 - How do the hair shaft and hair root differ?Ch. 5.5 - How does a hair grow in length?Ch. 5.5 - Prob. 3QCCh. 5.5 - Define the following terms: nail bed, nail plate,...Ch. 5.5 - How does nail growth occur?Ch. 5.5 - Prob. 6QCCh. 5.5 - What are the other three types of sweat glands,...Ch. 5.5 - 8. How do sebaceous glands and sebum differ from...Ch. 5.6 - Prob. 1QCCh. 5.6 - Prob. 2QCCh. 5.6 - What is cancer?Ch. 5.6 - 4. How do the three types of skin cancer differ?
Ch. 5 - Explain why the skin is an organ.Ch. 5 - Which of the following correctly describes the...Ch. 5 - Which of the following is not a function of the...Ch. 5 - 4. Explain what happens to dermal blood vessels...Ch. 5 - Number the strata of thick skin epidermis from...Ch. 5 - Keratinocytes in the superficial strata of the...Ch. 5 - Mark the following statements as true or false. If...Ch. 5 - Which of the following statements is false? a....Ch. 5 - What are the functions of the dermal papillae?Ch. 5 - Epidermal ridges are created by: a. the epidermal...Ch. 5 - 11. Mark the following statements as true or...Ch. 5 - 12. Which of the following is not a function of...Ch. 5 - 13. Fill in the blanks: The portion of the hair...Ch. 5 - Nail growth occurs when: a. cells in the nail...Ch. 5 - Prob. 15CYRCh. 5 - Match each type of gland with its correct...Ch. 5 - How do sweat and sebum differ?Ch. 5 - 18. Which type of burn involves the epidermis and...Ch. 5 - 19. The type of skin tumor that involves the...Ch. 5 - Prob. 1CYUCh. 5 - Prob. 2CYUCh. 5 - The hair and nails are sometimes called accessory...Ch. 5 - 1. You are working in the emergency department...Ch. 5 - 2. After Ramon’s skin came into contact with a...Ch. 5 - 3. Which of the following is not a function of...Ch. 5 - 4. What would happen to the skin if the oil...Ch. 5 - Many antiaging skin creams contain collagen and...Ch. 5 - 6. Would a mild second-degree burn be likely to...
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