Laboratory Manual for Holes Human Anatomy & Physiology Fetal Pig Version
14th Edition
ISBN: 9781259295645
Author: Terry R. Martin
Publisher: McGraw-Hill Education
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Chapter 5, Problem 4.4A
Electron micrographs represent extremely thin slices of cells. Each micrograph in figure 5.5 contains a section of a nucleus and some cytoplasm. Compare the organelles shown in these micrographs with organelles of the animal cell model and figure 5.1.
Using the terms provided, identify the structures indicated by the arrows in figure 5.5.
4. ________________________
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 5 Solutions
Laboratory Manual for Holes Human Anatomy & Physiology Fetal Pig Version
Ch. 5 - Match the cellular components in column A with the...Ch. 5 - Prob. 2.1ACh. 5 - Prob. 2.2ACh. 5 - Are the stained cheek cells nearly the same size...Ch. 5 - What do the various types of cells in these...Ch. 5 - What are the main differences you observed among...Ch. 5 - Electron micrographs represent extremely thin...Ch. 5 - Electron micrographs represent extremely thin...Ch. 5 - Electron micrographs represent extremely thin...Ch. 5 - Electron micrographs represent extremely thin...
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