BIOCHEM. II-EBOOK ACCESS>CUSTOM<
18th Edition
ISBN: 9781337700320
Author: GARRETT
Publisher: CENGAGE LEARNING (CUSTOM)
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Chapter 5, Problem 3P
Answers to all problems are at the end of this book. Detailed solutions are available in the Student Solutions Manual, Study Guide, and Problems Book.
Solving the Sequence of an Oligopeptide From Sequence Analysis Data Amino acid analysis of a decapeptide revealed the presence of the following products:
The following facts were observed:
- Neither car boxy peptidase A nor B treatment of the- decapeptide had any effect.
- Trypsin treatment yielded two tetrapcptides and free Lys.
- Clostripain treatment yielded a tetrapcptide and a hexapeptidc.
- Cyanogen bromide treatment yielded an octapeptide and a dipeptide of sequence NP (using the one-letter codes).
- Chymotrypsin treatment yielded two tripeptides and a telrapeptide. The N-terminal chymotryptic peptide had a net charge of — 1 at neutral pi I and a net charge of —3 al pH 12.
- One cycle of Ed man degradation gave the PTH derivative
What is the ammo acid sequence of this decapeptide?
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3. Which one of the compounds
below is the major product formed by
the reaction sequence shown here?
CH3 +
CH3NO2
NaOH
H2, Ni
?
nitromethane
acetophenone
OH
OH
HO HN-
u x x x x
Ph
A
HO
-NH2
HO
H
Ph
Ph
Ph
N-
H
B
Ph
NH2
D
E
4. Only ONE of the five compounds below can be prepared by an aldol condensation in
which a single carbonyl compound is treated with base. Which one is it?
To solve this problem, reverse the aldol condensation that formed each of these molecules to find out what two molecules
came together to make the products. The one in which the two molecules are identical is the answer.
Ph
Ph
ཚིག གནས ག ནཱ ཀ ན ཀནཱ
A
Ph
H
B
Ph
Ph
H
D
Ph.
Ph
Ph
E
H
5. Which one is the major organic
product obtained from the following
reaction sequence?
First, equimolar amounts of cyclopentanone and
LDA are mixed at -78°C. Then propionaldehyde
(propanal) is added. Addition of aqueous acid
completes the process.
LDA, -78°C.
1.
2. H₂O*
H
A
B
H
0
D
H
H
E
Chapter 5 Solutions
BIOCHEM. II-EBOOK ACCESS>CUSTOM<
Ch. 5 - Answers to all problems are at the end of this...Ch. 5 - Answers to all problems are at the end of this...Ch. 5 - Answers to all problems are at the end of this...Ch. 5 - Answers to all problems are at the end of this...Ch. 5 - Answers to all problems are at the end of this...Ch. 5 - Answers to all problems are at the end of this...Ch. 5 - Answers to all problems are at the end of this...Ch. 5 - Answers to all problems are at the end of this...Ch. 5 - Answers to all problems are at the end of this...Ch. 5 - Answers to all problems are at the end of this...
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