LooseLeaf for Human Anatomy
LooseLeaf for Human Anatomy
5th Edition
ISBN: 9781259285271
Author: Michael McKinley Dr., Valerie O'Loughlin, Elizabeth Pennefather-O'Brien
Publisher: McGraw-Hill Education
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Chapter 5, Problem 17WYL

What is the cause of increased sensitivity to the sun as we age?

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A patient visits her doctor with symptoms typical of a bladder infection. She is immediately prescribed an 800 mgdose of antibiotic (bioavailability = 1/2, t½ = 12 h). The corresponding plasma concentration of drug is found to be 96 micrograms/ml. What is the volume of distribution of this drug? Please round to the nearest liter.
A 10 mg/Kg dose of a drug is given by intravenous injection to a 20 Kg dog. What would the volume of distribution be if the drug had been given orally and only 50% of the drug was absorbed (the concentration of drug at time = 0 is 0.1 mg/L)? Be sure to show your work.
After oral administration of 10mg of a drug, 50% is absorbed and 40% of the amount absorbed is metabolized by the first pass effect. The bioavailable dose of this drug is  ______. Make sure to provide units for your answer. Show your work.

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