Anatomy & Physiology
5th Edition
ISBN: 9780321861580
Author: Marieb, Elaine N.
Publisher: Pearson College Div
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Textbook Question
Chapter 5, Problem 17CYU
Which cutaneous glands are associated with hair follicles?
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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine:
(a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip
MAKE SURE ANSWERS HAVE UNITS if appropriate.
SHOW ALL WORK, including equation used, variables used and each step to your solution.
2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0
Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present. Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…
The current nutrition labelling regulation in Hong Kong requires food manufacturer to list E+7 information on the package of pre-packaged food products. Do you think that more nutrients, such as calcium and cholesterol, shall be included?
Chapter 5 Solutions
Anatomy & Physiology
Ch. 5 - While walking baretoot in a barn, Jeremy stepped...Ch. 5 - The stratum basale is also called the stratum...Ch. 5 - Why are the desmosomes connecting the...Ch. 5 - Prob. 4CYUCh. 5 - Which layer of the dermis is responsible for...Ch. 5 - Which tissue of the hypodermis makes it a good...Ch. 5 - You have just gotten a paper cut. It is very...Ch. 5 - Melanin and carotene are two pigments that...Ch. 5 - Prob. 9CYUCh. 5 - Which alteration in skin color may indicate a...
Ch. 5 - What are the concentric regions of a hair shaft,...Ch. 5 - Prob. 12CYUCh. 5 - What is the role of an arrectorpili muscle?Ch. 5 - What is the function of the hair papilla?Ch. 5 - Why is the lunule of a nail white instead of pink...Ch. 5 - Why are nails so hard?Ch. 5 - Which cutaneous glands are associated with hair...Ch. 5 - Prob. 18CYUCh. 5 - Prob. 19CYUCh. 5 - Sebaceous glands are not found in thick skin. Why...Ch. 5 - What chemicals produced in the skin help provide...Ch. 5 - Which epidermal cells play a role in body...Ch. 5 - How is sunlight important to bone health?Ch. 5 - Prob. 24CYUCh. 5 - Which type of skin cancer develops from the...Ch. 5 - What name is given to the rule for recognizing the...Ch. 5 - The healing of burns and epidermal regeneration is...Ch. 5 - Prob. 28CYUCh. 5 - Which epidermal cell type is most numerous? (a)...Ch. 5 - Which cell functions as part of the immune system?...Ch. 5 - The epidermis provides a physical barrier due...Ch. 5 - Skin color is determined by (a) the amount of...Ch. 5 - The sensations of touch and pressure are picked up...Ch. 5 - Which is not a true statement about the papillary...Ch. 5 - Skin surface markings that reflect points of tight...Ch. 5 - Which of the following is not an epidermal...Ch. 5 - An arrector pili muscle (a) is associated with...Ch. 5 - Prob. 10RQCh. 5 - Sebum (a) lubricates the surface of the skin and...Ch. 5 - Prob. 12RQCh. 5 - Which epidermal cells are also called prickle...Ch. 5 - Is a bald man really hairless? Explain.Ch. 5 - You go to the beach to swim on an extremely hot,...Ch. 5 - Prob. 16RQCh. 5 - Describe the process of hair formation, and list...Ch. 5 - Prob. 18RQCh. 5 - Why are there no skin cancers that originate from...Ch. 5 - A man got his finger caught in a machine at the...Ch. 5 - Prob. 21RQCh. 5 - A common belief is that having your hair cut makes...Ch. 5 - Integumentary System A terrible collision between...Ch. 5 - Integumentary System A terrible collision between...Ch. 5 - Integumentary System A terrible collision between...Ch. 5 - Integumentary System A terrible collision between...
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