(a) Interpretation: Acetylating agents such as acetic anhydride react preferentially with primary amines , iodoacetate reacts preferentially with sulfhydryl group, and ATP- dependent kinases preferentially add a phosphoryl group to side-chain hydroxyl or phenolic- OH groups. From this it should be identified which amino acid side chains or main-chain groups, in a polypeptide are most likely to be modified by treated with acetic anhydride. Concept Introduction: Amino acid has one central carbon atom which is capable of having four covalent bonds. The other four parts of amino acids are bound to each central carbon atom. A unique chemical group is bonded to each amino acid which is known as its side chain. Proteins are large biological molecules made up of long chains of amino acid residues. Single polypeptide chain or two or more numbers of polypeptide chains are responsible for developing proteins. Proteins are the building block of the body. They have diverse functions like catalyzing metabolic reaction, DNA (deoxyribonucleic acid) replication, transporting hormones and other molecules throughout the body, and responding to different stimuli. Post-translational modification (PTM) is a biological process post protein translation in which enzymatic modification of protein takes place either during the process of translation or post protein biosynthesis.

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Answer 1

Question

Chapter 5, Problem 15P

Interpretation Introduction

(a) Interpretation:

Acetylating agents such as acetic anhydride react preferentially with primary amines, iodoacetate reacts preferentially with sulfhydryl group, and ATP- dependent kinases preferentially add a phosphoryl group to side-chain hydroxyl or phenolic- OH groups. From this it should be identified which amino acid side chains or main-chain groups, in a polypeptide are most likely to be modified by treated with acetic anhydride.

Concept Introduction:

Amino acid has one central carbon atom which is capable of having four covalent bonds. The other four parts of amino acids are bound to each central carbon atom. A unique chemical group is bonded to each amino acid which is known as its side chain.

Proteins are large biological molecules made up of long chains of amino acid residues. Single polypeptide chain or two or more numbers of polypeptide chains are responsible for developing proteins. Proteins are the building block of the body. They have diverse functions like catalyzing metabolic reaction, DNA (deoxyribonucleic acid) replication, transporting hormones and other molecules throughout the body, and responding to different stimuli. Post-translational modification (PTM) is a biological process post protein translation in which enzymatic modification of protein takes place either during the process of translation or post protein biosynthesis.

Interpretation Introduction

(b) Interpretation:

Acetylating agents such as acetic anhydride react preferentially with primary amines, iodoacetate reacts preferentially with sulfhydryl group, and ATP- dependent kinases preferentially add a phosphoryl group to side-chain hydroxyl or phenolic- OH groups. From this it should be identified which amino acid side chains or main-chain groups, in a polypeptide are most likely to be modified by treated with iodoacetate.

Concept Introduction:

Amino acid has one central carbon atom which is capable of having four covalent bonds. The other four parts of amino acids are bound to each central carbon atom. A unique chemical group is bonded to each amino acid which is known as its side chain.

Proteins are large biological molecules made up of long chains of amino acid residues. Single polypeptide chain or two or more numbers of polypeptide chains are responsible for developing proteins. Proteins are the building block of the body. They have diverse functions like catalyzing metabolic reaction, DNA (deoxyribonucleic acid) replication, transporting hormones and other molecules throughout the body, and responding to different stimuli. Post-translational modification (PTM) is a biological process post protein translation in which enzymatic modification of protein takes place either during the process of translation or post protein biosynthesis.

Interpretation Introduction

(c) Interpretation:

Acetylating agents such as acetic anhydride react preferentially with primary amines, iodoacetate reacts preferentially with sulfhydryl group, and ATP- dependent kinases preferentially add a phosphoryl group to side-chain hydroxyl or phenolic- OH groups. From this it should be identified which amino acid side chains or main-chain groups, in a polypeptide are most likely to be modified by treated with kinase + ATP.

Concept Introduction:

Amino acid has one central carbon atom which is capable of having four covalent bonds. The other four parts of amino acids are bound to each central carbon atom. A unique chemical group is bonded to each amino acid which is known as its side chain.

Proteins are large biological molecules made up of long chains of amino acid residues. Single polypeptide chain or two or more numbers of polypeptide chains are responsible for developing proteins. Proteins are the building block of the body. They have diverse functions like catalyzing metabolic reaction, DNA (deoxyribonucleic acid) replication, transporting hormones and other molecules throughout the body, and responding to different stimuli. Post-translational modification (PTM) is a biological process post protein translation in which enzymatic modification of protein takes place either during the process of translation or post protein biosynthesis.

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The beta-lactamase hydrolyzes the lactam-ring in penicillin. Describe the mechanism of hydrolysis, insuring to include the involvement of S, D, & K in the reaction sequence. Please help

To map the active site of beta-lactamase, the enzyme was hydrolyzed with trypsin to yield a hexapeptide (P1) with the following amino acids. Glu, Lys, Leu, Phe, Met, and Ser. Treatment of P1 with phenyl isothiocyanate yielded a PTH derivative of phenylalanine and a peptide (P2). Treatment of P1 with cyanogenbromide gave an acidic tetrapeptide (P3) and a dipeptide (P4).Treatment of P2 with 1-fluoro-2,4-dinitrobenzene, followed by complete hydrolysis, yields N-2,4-dinitrophenyl-Glu. P1, P2, and P3 contain the active site serine. Why doesn't D in this hexapeptide not participate in the hydrolysis of the beta-lactam ring even though S, K, and D are involved in the catalyst?

To map the active site of -lactamase, the enzyme was hydrolyzed with trypsin to yield a hexapeptide (P1) with the following amino acids. Glu, Lys, Leu, Phe, Met, and Ser. Treatment of P1 with phenyl isothiocyanate yielded a PTH derivative of phenylalanine and a peptide (P2). Treatment of P1 with cyanogenbromide gave an acidic tetrapeptide (P3) and a dipeptide (P4).Treatment of P2 with 1-fluoro-2,4-dinitrobenzene, followed by complete hydrolysis, yields N-2,4-dinitrophenyl-Glu. P1, P2, and P3 contain the active site serine. Using the experimental results described above derive the primary sequence of the active site hexapeptide. Please help!

Answer 2

Question

Chapter 5, Problem 15P

Interpretation Introduction

(a) Interpretation:

Acetylating agents such as acetic anhydride react preferentially with primary amines, iodoacetate reacts preferentially with sulfhydryl group, and ATP- dependent kinases preferentially add a phosphoryl group to side-chain hydroxyl or phenolic- OH groups. From this it should be identified which amino acid side chains or main-chain groups, in a polypeptide are most likely to be modified by treated with acetic anhydride.

Concept Introduction:

Amino acid has one central carbon atom which is capable of having four covalent bonds. The other four parts of amino acids are bound to each central carbon atom. A unique chemical group is bonded to each amino acid which is known as its side chain.

Proteins are large biological molecules made up of long chains of amino acid residues. Single polypeptide chain or two or more numbers of polypeptide chains are responsible for developing proteins. Proteins are the building block of the body. They have diverse functions like catalyzing metabolic reaction, DNA (deoxyribonucleic acid) replication, transporting hormones and other molecules throughout the body, and responding to different stimuli. Post-translational modification (PTM) is a biological process post protein translation in which enzymatic modification of protein takes place either during the process of translation or post protein biosynthesis.

Interpretation Introduction

(b) Interpretation:

Acetylating agents such as acetic anhydride react preferentially with primary amines, iodoacetate reacts preferentially with sulfhydryl group, and ATP- dependent kinases preferentially add a phosphoryl group to side-chain hydroxyl or phenolic- OH groups. From this it should be identified which amino acid side chains or main-chain groups, in a polypeptide are most likely to be modified by treated with iodoacetate.

Concept Introduction:

Amino acid has one central carbon atom which is capable of having four covalent bonds. The other four parts of amino acids are bound to each central carbon atom. A unique chemical group is bonded to each amino acid which is known as its side chain.

Proteins are large biological molecules made up of long chains of amino acid residues. Single polypeptide chain or two or more numbers of polypeptide chains are responsible for developing proteins. Proteins are the building block of the body. They have diverse functions like catalyzing metabolic reaction, DNA (deoxyribonucleic acid) replication, transporting hormones and other molecules throughout the body, and responding to different stimuli. Post-translational modification (PTM) is a biological process post protein translation in which enzymatic modification of protein takes place either during the process of translation or post protein biosynthesis.

Interpretation Introduction

(c) Interpretation:

Acetylating agents such as acetic anhydride react preferentially with primary amines, iodoacetate reacts preferentially with sulfhydryl group, and ATP- dependent kinases preferentially add a phosphoryl group to side-chain hydroxyl or phenolic- OH groups. From this it should be identified which amino acid side chains or main-chain groups, in a polypeptide are most likely to be modified by treated with kinase + ATP.

Concept Introduction:

Amino acid has one central carbon atom which is capable of having four covalent bonds. The other four parts of amino acids are bound to each central carbon atom. A unique chemical group is bonded to each amino acid which is known as its side chain.

Proteins are large biological molecules made up of long chains of amino acid residues. Single polypeptide chain or two or more numbers of polypeptide chains are responsible for developing proteins. Proteins are the building block of the body. They have diverse functions like catalyzing metabolic reaction, DNA (deoxyribonucleic acid) replication, transporting hormones and other molecules throughout the body, and responding to different stimuli. Post-translational modification (PTM) is a biological process post protein translation in which enzymatic modification of protein takes place either during the process of translation or post protein biosynthesis.

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Answer 3

Question

Chapter 5, Problem 15P

Interpretation Introduction

(a) Interpretation:

Acetylating agents such as acetic anhydride react preferentially with primary amines, iodoacetate reacts preferentially with sulfhydryl group, and ATP- dependent kinases preferentially add a phosphoryl group to side-chain hydroxyl or phenolic- OH groups. From this it should be identified which amino acid side chains or main-chain groups, in a polypeptide are most likely to be modified by treated with acetic anhydride.

Concept Introduction:

Amino acid has one central carbon atom which is capable of having four covalent bonds. The other four parts of amino acids are bound to each central carbon atom. A unique chemical group is bonded to each amino acid which is known as its side chain.

Proteins are large biological molecules made up of long chains of amino acid residues. Single polypeptide chain or two or more numbers of polypeptide chains are responsible for developing proteins. Proteins are the building block of the body. They have diverse functions like catalyzing metabolic reaction, DNA (deoxyribonucleic acid) replication, transporting hormones and other molecules throughout the body, and responding to different stimuli. Post-translational modification (PTM) is a biological process post protein translation in which enzymatic modification of protein takes place either during the process of translation or post protein biosynthesis.

Interpretation Introduction

(b) Interpretation:

Acetylating agents such as acetic anhydride react preferentially with primary amines, iodoacetate reacts preferentially with sulfhydryl group, and ATP- dependent kinases preferentially add a phosphoryl group to side-chain hydroxyl or phenolic- OH groups. From this it should be identified which amino acid side chains or main-chain groups, in a polypeptide are most likely to be modified by treated with iodoacetate.

Concept Introduction:

Amino acid has one central carbon atom which is capable of having four covalent bonds. The other four parts of amino acids are bound to each central carbon atom. A unique chemical group is bonded to each amino acid which is known as its side chain.

Proteins are large biological molecules made up of long chains of amino acid residues. Single polypeptide chain or two or more numbers of polypeptide chains are responsible for developing proteins. Proteins are the building block of the body. They have diverse functions like catalyzing metabolic reaction, DNA (deoxyribonucleic acid) replication, transporting hormones and other molecules throughout the body, and responding to different stimuli. Post-translational modification (PTM) is a biological process post protein translation in which enzymatic modification of protein takes place either during the process of translation or post protein biosynthesis.

Interpretation Introduction

(c) Interpretation:

Acetylating agents such as acetic anhydride react preferentially with primary amines, iodoacetate reacts preferentially with sulfhydryl group, and ATP- dependent kinases preferentially add a phosphoryl group to side-chain hydroxyl or phenolic- OH groups. From this it should be identified which amino acid side chains or main-chain groups, in a polypeptide are most likely to be modified by treated with kinase + ATP.

Concept Introduction:

Amino acid has one central carbon atom which is capable of having four covalent bonds. The other four parts of amino acids are bound to each central carbon atom. A unique chemical group is bonded to each amino acid which is known as its side chain.

Proteins are large biological molecules made up of long chains of amino acid residues. Single polypeptide chain or two or more numbers of polypeptide chains are responsible for developing proteins. Proteins are the building block of the body. They have diverse functions like catalyzing metabolic reaction, DNA (deoxyribonucleic acid) replication, transporting hormones and other molecules throughout the body, and responding to different stimuli. Post-translational modification (PTM) is a biological process post protein translation in which enzymatic modification of protein takes place either during the process of translation or post protein biosynthesis.

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Check out a sample textbook solution

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Answer 4

Question

Chapter 5, Problem 15P

Interpretation Introduction

(a) Interpretation:

Acetylating agents such as acetic anhydride react preferentially with primary amines, iodoacetate reacts preferentially with sulfhydryl group, and ATP- dependent kinases preferentially add a phosphoryl group to side-chain hydroxyl or phenolic- OH groups. From this it should be identified which amino acid side chains or main-chain groups, in a polypeptide are most likely to be modified by treated with acetic anhydride.

Concept Introduction:

Amino acid has one central carbon atom which is capable of having four covalent bonds. The other four parts of amino acids are bound to each central carbon atom. A unique chemical group is bonded to each amino acid which is known as its side chain.

Proteins are large biological molecules made up of long chains of amino acid residues. Single polypeptide chain or two or more numbers of polypeptide chains are responsible for developing proteins. Proteins are the building block of the body. They have diverse functions like catalyzing metabolic reaction, DNA (deoxyribonucleic acid) replication, transporting hormones and other molecules throughout the body, and responding to different stimuli. Post-translational modification (PTM) is a biological process post protein translation in which enzymatic modification of protein takes place either during the process of translation or post protein biosynthesis.

Interpretation Introduction

(b) Interpretation:

Acetylating agents such as acetic anhydride react preferentially with primary amines, iodoacetate reacts preferentially with sulfhydryl group, and ATP- dependent kinases preferentially add a phosphoryl group to side-chain hydroxyl or phenolic- OH groups. From this it should be identified which amino acid side chains or main-chain groups, in a polypeptide are most likely to be modified by treated with iodoacetate.

Concept Introduction:

Amino acid has one central carbon atom which is capable of having four covalent bonds. The other four parts of amino acids are bound to each central carbon atom. A unique chemical group is bonded to each amino acid which is known as its side chain.

Proteins are large biological molecules made up of long chains of amino acid residues. Single polypeptide chain or two or more numbers of polypeptide chains are responsible for developing proteins. Proteins are the building block of the body. They have diverse functions like catalyzing metabolic reaction, DNA (deoxyribonucleic acid) replication, transporting hormones and other molecules throughout the body, and responding to different stimuli. Post-translational modification (PTM) is a biological process post protein translation in which enzymatic modification of protein takes place either during the process of translation or post protein biosynthesis.

Interpretation Introduction

(c) Interpretation:

Acetylating agents such as acetic anhydride react preferentially with primary amines, iodoacetate reacts preferentially with sulfhydryl group, and ATP- dependent kinases preferentially add a phosphoryl group to side-chain hydroxyl or phenolic- OH groups. From this it should be identified which amino acid side chains or main-chain groups, in a polypeptide are most likely to be modified by treated with kinase + ATP.

Concept Introduction:

Amino acid has one central carbon atom which is capable of having four covalent bonds. The other four parts of amino acids are bound to each central carbon atom. A unique chemical group is bonded to each amino acid which is known as its side chain.

Proteins are large biological molecules made up of long chains of amino acid residues. Single polypeptide chain or two or more numbers of polypeptide chains are responsible for developing proteins. Proteins are the building block of the body. They have diverse functions like catalyzing metabolic reaction, DNA (deoxyribonucleic acid) replication, transporting hormones and other molecules throughout the body, and responding to different stimuli. Post-translational modification (PTM) is a biological process post protein translation in which enzymatic modification of protein takes place either during the process of translation or post protein biosynthesis.

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Check out a sample textbook solution

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Answer 5

Chapter 5, Problem 15P

Interpretation Introduction

(a) Interpretation:

Acetylating agents such as acetic anhydride react preferentially with primary amines, iodoacetate reacts preferentially with sulfhydryl group, and ATP- dependent kinases preferentially add a phosphoryl group to side-chain hydroxyl or phenolic- OH groups. From this it should be identified which amino acid side chains or main-chain groups, in a polypeptide are most likely to be modified by treated with acetic anhydride.

Concept Introduction:

Amino acid has one central carbon atom which is capable of having four covalent bonds. The other four parts of amino acids are bound to each central carbon atom. A unique chemical group is bonded to each amino acid which is known as its side chain.

Proteins are large biological molecules made up of long chains of amino acid residues. Single polypeptide chain or two or more numbers of polypeptide chains are responsible for developing proteins. Proteins are the building block of the body. They have diverse functions like catalyzing metabolic reaction, DNA (deoxyribonucleic acid) replication, transporting hormones and other molecules throughout the body, and responding to different stimuli. Post-translational modification (PTM) is a biological process post protein translation in which enzymatic modification of protein takes place either during the process of translation or post protein biosynthesis.

Interpretation Introduction

(b) Interpretation:

Acetylating agents such as acetic anhydride react preferentially with primary amines, iodoacetate reacts preferentially with sulfhydryl group, and ATP- dependent kinases preferentially add a phosphoryl group to side-chain hydroxyl or phenolic- OH groups. From this it should be identified which amino acid side chains or main-chain groups, in a polypeptide are most likely to be modified by treated with iodoacetate.

Concept Introduction:

Amino acid has one central carbon atom which is capable of having four covalent bonds. The other four parts of amino acids are bound to each central carbon atom. A unique chemical group is bonded to each amino acid which is known as its side chain.

Proteins are large biological molecules made up of long chains of amino acid residues. Single polypeptide chain or two or more numbers of polypeptide chains are responsible for developing proteins. Proteins are the building block of the body. They have diverse functions like catalyzing metabolic reaction, DNA (deoxyribonucleic acid) replication, transporting hormones and other molecules throughout the body, and responding to different stimuli. Post-translational modification (PTM) is a biological process post protein translation in which enzymatic modification of protein takes place either during the process of translation or post protein biosynthesis.

Interpretation Introduction

(c) Interpretation:

Acetylating agents such as acetic anhydride react preferentially with primary amines, iodoacetate reacts preferentially with sulfhydryl group, and ATP- dependent kinases preferentially add a phosphoryl group to side-chain hydroxyl or phenolic- OH groups. From this it should be identified which amino acid side chains or main-chain groups, in a polypeptide are most likely to be modified by treated with kinase + ATP.

Concept Introduction:

Amino acid has one central carbon atom which is capable of having four covalent bonds. The other four parts of amino acids are bound to each central carbon atom. A unique chemical group is bonded to each amino acid which is known as its side chain.

Proteins are large biological molecules made up of long chains of amino acid residues. Single polypeptide chain or two or more numbers of polypeptide chains are responsible for developing proteins. Proteins are the building block of the body. They have diverse functions like catalyzing metabolic reaction, DNA (deoxyribonucleic acid) replication, transporting hormones and other molecules throughout the body, and responding to different stimuli. Post-translational modification (PTM) is a biological process post protein translation in which enzymatic modification of protein takes place either during the process of translation or post protein biosynthesis.

Answer 6

Chapter 5, Problem 15P

Interpretation Introduction

(a) Interpretation:

Acetylating agents such as acetic anhydride react preferentially with primary amines, iodoacetate reacts preferentially with sulfhydryl group, and ATP- dependent kinases preferentially add a phosphoryl group to side-chain hydroxyl or phenolic- OH groups. From this it should be identified which amino acid side chains or main-chain groups, in a polypeptide are most likely to be modified by treated with acetic anhydride.

Concept Introduction:

Amino acid has one central carbon atom which is capable of having four covalent bonds. The other four parts of amino acids are bound to each central carbon atom. A unique chemical group is bonded to each amino acid which is known as its side chain.

Proteins are large biological molecules made up of long chains of amino acid residues. Single polypeptide chain or two or more numbers of polypeptide chains are responsible for developing proteins. Proteins are the building block of the body. They have diverse functions like catalyzing metabolic reaction, DNA (deoxyribonucleic acid) replication, transporting hormones and other molecules throughout the body, and responding to different stimuli. Post-translational modification (PTM) is a biological process post protein translation in which enzymatic modification of protein takes place either during the process of translation or post protein biosynthesis.

Answer 7

Chapter 5, Problem 15P

Interpretation Introduction

(a) Interpretation:

Acetylating agents such as acetic anhydride react preferentially with primary amines, iodoacetate reacts preferentially with sulfhydryl group, and ATP- dependent kinases preferentially add a phosphoryl group to side-chain hydroxyl or phenolic- OH groups. From this it should be identified which amino acid side chains or main-chain groups, in a polypeptide are most likely to be modified by treated with acetic anhydride.

Concept Introduction:

Amino acid has one central carbon atom which is capable of having four covalent bonds. The other four parts of amino acids are bound to each central carbon atom. A unique chemical group is bonded to each amino acid which is known as its side chain.

Proteins are large biological molecules made up of long chains of amino acid residues. Single polypeptide chain or two or more numbers of polypeptide chains are responsible for developing proteins. Proteins are the building block of the body. They have diverse functions like catalyzing metabolic reaction, DNA (deoxyribonucleic acid) replication, transporting hormones and other molecules throughout the body, and responding to different stimuli. Post-translational modification (PTM) is a biological process post protein translation in which enzymatic modification of protein takes place either during the process of translation or post protein biosynthesis.

Answer 8

Interpretation Introduction

(b) Interpretation:

Acetylating agents such as acetic anhydride react preferentially with primary amines, iodoacetate reacts preferentially with sulfhydryl group, and ATP- dependent kinases preferentially add a phosphoryl group to side-chain hydroxyl or phenolic- OH groups. From this it should be identified which amino acid side chains or main-chain groups, in a polypeptide are most likely to be modified by treated with iodoacetate.

Concept Introduction:

Amino acid has one central carbon atom which is capable of having four covalent bonds. The other four parts of amino acids are bound to each central carbon atom. A unique chemical group is bonded to each amino acid which is known as its side chain.

Proteins are large biological molecules made up of long chains of amino acid residues. Single polypeptide chain or two or more numbers of polypeptide chains are responsible for developing proteins. Proteins are the building block of the body. They have diverse functions like catalyzing metabolic reaction, DNA (deoxyribonucleic acid) replication, transporting hormones and other molecules throughout the body, and responding to different stimuli. Post-translational modification (PTM) is a biological process post protein translation in which enzymatic modification of protein takes place either during the process of translation or post protein biosynthesis.

Answer 9

Interpretation Introduction

(b) Interpretation:

Acetylating agents such as acetic anhydride react preferentially with primary amines, iodoacetate reacts preferentially with sulfhydryl group, and ATP- dependent kinases preferentially add a phosphoryl group to side-chain hydroxyl or phenolic- OH groups. From this it should be identified which amino acid side chains or main-chain groups, in a polypeptide are most likely to be modified by treated with iodoacetate.

Concept Introduction:

Amino acid has one central carbon atom which is capable of having four covalent bonds. The other four parts of amino acids are bound to each central carbon atom. A unique chemical group is bonded to each amino acid which is known as its side chain.

Proteins are large biological molecules made up of long chains of amino acid residues. Single polypeptide chain or two or more numbers of polypeptide chains are responsible for developing proteins. Proteins are the building block of the body. They have diverse functions like catalyzing metabolic reaction, DNA (deoxyribonucleic acid) replication, transporting hormones and other molecules throughout the body, and responding to different stimuli. Post-translational modification (PTM) is a biological process post protein translation in which enzymatic modification of protein takes place either during the process of translation or post protein biosynthesis.

Answer 10

Interpretation Introduction

(c) Interpretation:

Acetylating agents such as acetic anhydride react preferentially with primary amines, iodoacetate reacts preferentially with sulfhydryl group, and ATP- dependent kinases preferentially add a phosphoryl group to side-chain hydroxyl or phenolic- OH groups. From this it should be identified which amino acid side chains or main-chain groups, in a polypeptide are most likely to be modified by treated with kinase + ATP.

Concept Introduction:

Amino acid has one central carbon atom which is capable of having four covalent bonds. The other four parts of amino acids are bound to each central carbon atom. A unique chemical group is bonded to each amino acid which is known as its side chain.

Proteins are large biological molecules made up of long chains of amino acid residues. Single polypeptide chain or two or more numbers of polypeptide chains are responsible for developing proteins. Proteins are the building block of the body. They have diverse functions like catalyzing metabolic reaction, DNA (deoxyribonucleic acid) replication, transporting hormones and other molecules throughout the body, and responding to different stimuli. Post-translational modification (PTM) is a biological process post protein translation in which enzymatic modification of protein takes place either during the process of translation or post protein biosynthesis.

Answer 11

Interpretation Introduction

(c) Interpretation:

Acetylating agents such as acetic anhydride react preferentially with primary amines, iodoacetate reacts preferentially with sulfhydryl group, and ATP- dependent kinases preferentially add a phosphoryl group to side-chain hydroxyl or phenolic- OH groups. From this it should be identified which amino acid side chains or main-chain groups, in a polypeptide are most likely to be modified by treated with kinase + ATP.

Concept Introduction:

Amino acid has one central carbon atom which is capable of having four covalent bonds. The other four parts of amino acids are bound to each central carbon atom. A unique chemical group is bonded to each amino acid which is known as its side chain.

Proteins are large biological molecules made up of long chains of amino acid residues. Single polypeptide chain or two or more numbers of polypeptide chains are responsible for developing proteins. Proteins are the building block of the body. They have diverse functions like catalyzing metabolic reaction, DNA (deoxyribonucleic acid) replication, transporting hormones and other molecules throughout the body, and responding to different stimuli. Post-translational modification (PTM) is a biological process post protein translation in which enzymatic modification of protein takes place either during the process of translation or post protein biosynthesis.

Answer 12

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Answer 13

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Answer 14

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Answer 15

Ch. 5 - Prob. 1P Ch. 5 - Draw the structure of the peptide DTLH, showing...Ch. 5 - Prob. 3P Ch. 5 - Prob. 4P Ch. 5 - Prob. 5P Ch. 5 - Prob. 6P Ch. 5 - Prob. 7P Ch. 5 - Given the following peptide SEPIMAPVEYPK a....Ch. 5 - A mutant form of polypeptide hormone angiotensin...Ch. 5 - Prob. 10P

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