CAMPBELL'S BIOLOGY 12E PERUSALL
CAMPBELL'S BIOLOGY 12E PERUSALL
12th Edition
ISBN: 9780135858080
Author: Urry
Publisher: PERUSALL
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Chapter 47.3, Problem 4CC
Summary Introduction

To explain: The expected result, when zone of polarizing activity (ZPA) is removed from a limb bud and then a bead dripped in sonic hedgehog is placed in the center of the limb bud.

Concept introduction: The limb bud development is determined by two regions – the apical ectodermal ridge (AER) and the zone of polarizing activity (ZPA). The AER region determines the growth of a limb along the proximal-distal axis. The ZPA region determines the growth of the limb along the anterior-posterior axis.

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Imagine that you are a clinical geneticist. Your colleague is an oncologist who wants your help explaining the basics of genetics to their patient, who will be undergoing genetic testing in the coming weeks for possible acute myeloid leukemia (AML) induced by the radiation she had several years ago for breast cancer. Write a 1,050- to 1,225-word memo to your colleague. Include the following in your memo: An explanation of the molecular structure of DNA and RNA, highlighting both similarities and differences  A description of the processes of transcription and translation An explanation of the differences between leading and lagging strands and how the DNA is replicated in each strand Reponses to the following common questions patients might ask about this type of genetic testing and genetic disorder: Does AML run in families? What genes are tested for?
Respond to the following in a minimum of 175 words: What are some potential consequences that could result if the processes of replication, transcription, and translation don’t function correctly? Provide an example of how you might explain these consequences in terms that patients might understand.
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