The expected result, when zone of polarizing activity (ZPA) is removed from a limb bud and then a bead dripped in sonic hedgehog is placed in the center of the limb bud. Concept introduction: The limb bud development is determined by two regions – the apical ectodermal ridge (AER) and the zone of polarizing activity (ZPA). The AER region determines the growth of a limb along the proximal-distal axis. The ZPA region determines the growth of the limb along the anterior-posterior axis.

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Chapter 47.3, Problem 4CC

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To explain: The expected result, when zone of polarizing activity (ZPA) is removed from a limb bud and then a bead dripped in sonic hedgehog is placed in the center of the limb bud.

Concept introduction: The limb bud development is determined by two regions – the apical ectodermal ridge (AER) and the zone of polarizing activity (ZPA). The AER region determines the growth of a limb along the proximal-distal axis. The ZPA region determines the growth of the limb along the anterior-posterior axis.

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