BIOLOGY
BIOLOGY
5th Edition
ISBN: 9781265202859
Author: BROOKER
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Chapter 46.4, Problem 1CS
Summary Introduction

To describe: A hypothesis, which explains lactose intolerance in most of human adults.

Introduction: lactose is a primary disaccharide available widely in milk and dairy products.. Lactose is a carbohydrate which is a source of energy in the body. Lactose is sweet in nature and majorly found in milk products. Lactose intolerance is a major metabolism error which occurs mostly in adults.

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You aim to test the hypothesis that the Tbx4 and Tbx5 genes inhibit each other's expression during limb development. With access to chicken embryos and viruses capable of overexpressing Tbx4 and Tbx5, describe an experiment to investigate whether these genes suppress each other's expression in the limb buds. What results would you expect if they do repress each other? What results would you expect if they do not repress each other?
You decide to delete Fgf4 and Fgf8 specifically in the limb bud. Explain why you would not knock out these genes in the entire embryo instead.
You implant an FGF10-coated bead into the anterior flank of a chicken embryo, directly below the level of the wing bud. What is the phenotype of the resulting ectopic limb?  Briefly describe the expected expression domains of 1) Shh, 2) Tbx4, and 3) Tbx5 in the resulting ectopic limb bud.
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