Pharmacology and the Nursing Process, 8e
Pharmacology and the Nursing Process, 8e
8th Edition
ISBN: 9780323358286
Author: Linda Lane Lilley PhD RN, Shelly Rainforth Collins PharmD, Julie S. Snyder MSN RN-BC
Publisher: Elsevier Science
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Chapter 45, Problem 1O
Summary Introduction

To describe:

Concepts related to carcinogenesis.

Concept introduction:

Cancer cells are characterized by the uncontrolled proliferation of abnormal cells, invasion, and metastasis. Drugs, which are used to treat cancer is generally known as chemotherapeutic drugs or antineoplastic drugs. Antineoplastic drugs are broadly classified into two categories based on targeting the phases of the cell cycle (cell cycle specific drugs and cell cycle non-specific drugs). The major adverse effects of chemotherapy are immune suppression, gastrointestinal distress, fatigue, anemia, nausea, vomiting, hair loss, and stomatitis. Most of the antineoplastic drugs cause adverse effects on rapidly dividing cells (for example, bone marrow cells, GI tract cells, and hair follicles).

Expert Solution & Answer
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Explanation of Solution

Carcinogenesis is also known as tumorigenesis, is the progression of cancer. Cancer is a group of diseases in which normal cell is transformed into genetically abnormal cells. Cancer is characterized by genetic or cellular changes, uncontrolled growth of cells, invasion, metastasis, and antiapoptosis. Cancer cells lack differentiation and maturation into specialized cells. Cancer cells invade adjacent tissues and travel to other parts of the body through the blood or lymphatic system.

The clone is a single cancer cell or group of cancer cells and that is produced from the genetically identical parent cell. The establishment of the new clone of cancer cells paves the way for metastasis. Spread of cancer cells from their original site to other organs or parts of the body is known as metastasis.

Carcinogenesis is a multistep process, there are four major stages are found in carcinogenesis are initiation (alteration or mutation of genes by spontaneous or induced), promotion (invasion and clonal expansion), conversion (genetic changes), and progression (genetic as well as phenotypic changes and cancer proliferation).

The term tumor, malignancy, and neoplasm are synonyms for cancer. Neoplasm refers as a mass of new tissue or new cells. The tumor is classified into two: benign and malignant. Uniform size and shape of cells without invasion is called benign tumor and it may be harmless. Invasion of cancer cells to their surrounding area and other parts is known as a malignant tumor.

Various types of cancer are classified based on tissues, such as sarcomas (connective tissues), carcinomas (epithelial tissues), lymphomas (lymphatic tissues), leukemias (blood), and cancers of nervous tissues.

Conclusion

Carcinogenesis is the progression of cancer or tumor. It is a multistep process and mainly categorized into the benign tumor and the malignant tumor.

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