CAMPBELL BIOLOGY-MASTERING BIO.ACCESS
CAMPBELL BIOLOGY-MASTERING BIO.ACCESS
12th Edition
ISBN: 9780136486787
Author: Urry
Publisher: SAVVAS L
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Chapter 44.5, Problem 2CC
Summary Introduction

To determine: The reason for the development of a dangerous condition, if substantial amounts of water is ingested in a brief period of time.

Concept introduction: The increase in the osmolarity of the blood causes the generation of the thirsty condition. This leads to the release of the antidiuretic hormone from the posterior pituitary gland, which results in the water reabsorption in the collecting duct. The intake of the excess water causes the release of excessive amounts of the dilute urine from the body. The osmolarity of the ions in the blood decreases after the intake of water.

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a. What percentage of a drug is eliminated after 4 half-lives? Please round to the nearest percent.  b. What will happen to elimination of the drug in the previous question if the system is saturated? explain and show any math involved
If you wanted to reduce the difference between peak and trough levels that occur with repeated administration of a drug, how would you adjust the dose and dose interval without changing the plateau concentration (plateau is the average of peak and trough levels)? Select your answers for both dose and interval. Hint: It may be helpful to think about this problem using an example such as food. How would you eat if you wanted to maintain very steady hunger/satiety levels without changing your total caloric intake? Options: A. Dose; Increase dose     B. Dose; Decrease dose     C. Dose; Do not change dose     D. Interval; Increase the interval between doses (give the drug less frequently)    E. Interval; Decrease the interval between doses (give the drug more frequently)     F. Interval; Do not change the interval
What percentage of a drug is eliminated after 4 half-lives? Please round to the nearest percent. Show the math
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