Laboratory Manual for Human Anatomy & Physiology (Cat Version)
4th Edition
ISBN: 9781259864612
Author: Martin
Publisher: MCGRAW-HILL HIGHER EDUCATION
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Chapter 42, Problem 2.3A
Summary Introduction
To analyze:
The process of the comparing coagulation time from the blood test with the normal value and the test results can be changed in specific situations.
Introduction:
Coagulation time is the time from the start of bleeding until the clot formed.Coagulation is formed of clot when the injuries, the injured tissue and platelets release chemicals that trigger the clotting cascade which results in thrombin converting soluble fibrinogen into insoluble Fibrin. Fibrin traps Red blood cells and forms the clot.
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
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(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
Chapter 42 Solutions
Laboratory Manual for Human Anatomy & Physiology (Cat Version)
Ch. 42 - Prob. 1PLCh. 42 - Prob. 2PLCh. 42 - Prob. 3PLCh. 42 - Prob. 4PLCh. 42 - Coagulation should normally occur within a. 10...Ch. 42 - Prob. 6PLCh. 42 - A normal blood total cholesterol level is less...Ch. 42 - The high-density lipoproteins (HDLs) are sometimes...Ch. 42 - Prob. 1.1CTCh. 42 - Prob. 2.1A
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