HOLES HUMAN ANATOMY AND PHYSIOLOGY
15th Edition
ISBN: 9781307233995
Author: SHIER
Publisher: MCG
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Chapter 4, Problem 9CA
Summary Introduction
To describe:
The way in which negative feedback including rate-limiting enzyme controls a
Introduction:
Negative feedback mechanism refers to a type of mechanism, in which the product reduces the original effect of the reaction. The formation of a product inhibits its own synthesis by sending signals of negative feedback.
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19. On the diagram below
a. Label the three pictures as: DNA; polypeptide; or RNA.
b. Label the arrows as: translation or transcription/RNA processing.
c. Add the following details to the diagram.
Promoter region
TATA box
Transcription start site
Transcription terminator
Intron (A,B,C,D)
Exons (1,2,3,4,5)
Splice sites
5' cap
5' UTR (untranslated region)
3' poly A tail
3' UTR (untranslated region)
Translational start (AUG)
Translational stop (UGA, UAG, or UAA)
N and C ends of polypeptide
0000
Match the letter labels in the figure below to the terms. Some letter
labels are not used.
MNNNNNNIN
M
C
B
A
M
D
F
E
H
K
G
8
The diagram below illustrates a quorum sensing pathway from Staphylococcus aureus. Please answer the following questions.
1. Autoinduction is part of the quorum sensing system. Which promoter (P2 or P3) is critical for autoinduction?
2)This staphylococcus aureus grows on human wounds, causing severe infections. You would like to start a clinical trial to treat these wound infections. Please describe:
a) What molecule do you recommend for the trial. Why?
b) Your trial requires that Staphylococcus aureus be isolated from the wound and submitted to genome sequencing before admittance. Why? What are you testing for?
3) If a mutation arises where the Promoter P3 is constitutively active, how would that influence sensitivity to AIP? Please explain your rationale.
4) This pathway is sensitive to bacterial cell density. Describe two separate mutation that would render the pathway active independent of cell density. Briefly explain your rationale.
Mutation 1
Mutation 2
Chapter 4 Solutions
HOLES HUMAN ANATOMY AND PHYSIOLOGY
Ch. 4 - Prob. 1PCh. 4 - 2 What type of molecule is formed by the anabolism...Ch. 4 - Distinguish between dehydration synthesis and...Ch. 4 - Prob. 4PCh. 4 - Prob. 5PCh. 4 - Prob. 6PCh. 4 - Prob. 7PCh. 4 - Prob. 8PCh. 4 - Prob. 9PCh. 4 - Prob. 10P
Ch. 4 - Prob. 11PCh. 4 - Prob. 12PCh. 4 - Prob. 13PCh. 4 - Prob. 14PCh. 4 - Prob. 15PCh. 4 - Prob. 16PCh. 4 - Prob. 17PCh. 4 - Prob. 18PCh. 4 - Prob. 19PCh. 4 - Prob. 20PCh. 4 - 21 Define genetic code.
Ch. 4 - Prob. 22PCh. 4 - Prob. 23PCh. 4 - Prob. 24PCh. 4 - Prob. 25PCh. 4 - 26 Explain how genetic information is carried from...Ch. 4 - Prob. 27PCh. 4 - Prob. 28PCh. 4 - Prob. 29PCh. 4 - Prob. 30PCh. 4 - Prob. 31PCh. 4 - Prob. 32PCh. 4 - Distinguish between anabolism and catabolism. (p....Ch. 4 - Prob. 2CACh. 4 - Prob. 3CACh. 4 - 4 Describe how an enzyme interacts with its...Ch. 4 - Prob. 5CACh. 4 - Prob. 6CACh. 4 - Prob. 7CACh. 4 - 8 Explain the importance of a rate-limiting...Ch. 4 - Prob. 9CACh. 4 - Prob. 10CACh. 4 - Prob. 11CACh. 4 - Prob. 12CACh. 4 - Prob. 13CACh. 4 - Explain how the oxidation of molecules inside...Ch. 4 - Prob. 15CACh. 4 - Prob. 16CACh. 4 - Prob. 17CACh. 4 - Prob. 18CACh. 4 - Prob. 19CACh. 4 - Prob. 20CACh. 4 - Prob. 21CACh. 4 - Distinguish among a gene, an exome, and a genome....Ch. 4 - Define gene expression. (p. 132)Ch. 4 - Prob. 24CACh. 4 - Prob. 25CACh. 4 - Prob. 26CACh. 4 - Prob. 27CACh. 4 - Prob. 28CACh. 4 - Prob. 29CACh. 4 - Prob. 30CACh. 4 - Prob. 31CACh. 4 - Prob. 32CACh. 4 - Prob. 33CACh. 4 - Prob. 34CACh. 4 - Prob. 35CACh. 4 - Prob. 36CACh. 4 - Prob. 37CACh. 4 - Discuss three ways that the genetic code protects...Ch. 4 - How can the same molecule be both a reactant...Ch. 4 - Prob. 2IACh. 4 - Prob. 3IACh. 4 - Prob. 4IACh. 4 - Prob. 5IACh. 4 - Consider the following DNA sequence:...Ch. 4 - Prob. 7IA
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