Explanation Given information: The statement “If the slope of the dose/response curve is large, a small change in the dose will have a large effect on the response”. A dose-response curve plots the intensity of physiological response to a drug as a function of the dose administered. As the dose increases, the intensity of the response increases, so a dose-response function is increasing. The intensity of the response is generally scaled as a percentage of the maximum response. The curve cannot go above the maximum response (or 100%), so the curve levels off at a horizontal asymptote. Dose-response curves are generally concave up for low doses and concave down for high doses. A dose-response curve can be modeled by a logistic function with the independent variable being the dose of the drug, not time. A dose-response curve shows the amount of drug needed to produce the desired effect, as well as the maximum effect attainable and the dose required to obtain it...

6th Edition

ISBN: 9781119267874

Author: Hughes-Hallett

Publisher: WILEY

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Chapter 4, Problem 66SYU

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Chapter 4, Problem 65SYU

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Solution Summary: The author explains how the dose-response curve plots the intensity of physiological response to a drug. The slope of the curve gives information about the therapeutic safety margin.