Genetics: From Genes to Genomes, 5th edition
5th Edition
ISBN: 9780073525310
Author: Leland H. Hartwell, Michael L. Goldberg, Janice A. Fischer, Leroy Hood, Charles F. Aquadro
Publisher: McGraw-Hill Education
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Textbook Question
Chapter 4, Problem 45P
The pedigree at the bottom of the page shows the inheritance of various types of cancer in a particular family. Molecular analyses (described in subsequent chapters) indicate that with one exception, the cancers occurring in the patients in this pedigree as associ- ated with a rare mutation in a gene called BRCA2.
| a. | Which individual is the exceptional cancer patient whose disease is not associated with a BRCA2 mutation? |
| b. | Is the BRCA2 mutation dominant or recessive to the normal BRCA2 allele in terms of its cancer-causing effects? |
| c. | Is the BRCA2 gene likely to reside on the X chromosome, the Y chromosome, or an autosome? How definitive is your assignment of the chromosome carrying BRCA2?  |
| d. | Is the penetrance of the cancer phenotype complete or incomplete? |
| e. | Is the expressivity of the cancer phenotype unvarying or variable? |
| f. | Are any of the cancer |
| g. | How can you explain the absence of individuals diagnosed with cancer in generations I and II? |
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temperature and light on the yield of tomatoes in two greenhouses on a farm
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TEMPERATURE
(°C)
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Explain why you chose this mutation. Begin by transcribing and translating BOTH the
normal and abnormal DNA sequences. The genetic code below is for your reference.
SECOND BASE OF CODON
כ
FIRST BASE OF CODON
O
THIRD BASE OF CODON
SCAGUCAGUGAGUCAG
UUU
UUC
UCU
UAU
UGU
Phenylalanine
(F)
Tyrosine (Y)
Cysteine (C)
UCC
UAC
UGC
Serine (S)
UUA
UUG
Leucine (L)
UCA
UCG_
UAA
UGA
Stop codon
-Stop codon
UAG
UGG -Tryptophan (W)
CUU
CUC
CCU
CAU
CGU
Histidine (H)
CCC
CAC
CGC
-Leucine (L)
Proline (P)
CUA
CCA
CAA
CUG
CCG
CAG-Glutamine (Q)
-Arginine (R)
CGA
CGG
AUU
ACU
AAU
AGU
AUC
Isoleucine (1)
Asparagine (N)
ACC
AAC
Threonine (T)
AUA
ACA
AAA
Methionine (M)
Lysine (K)
AUG
ACG
Start codon
AAG
AGC-Serine (S)
-Arginine (R)
AGA
AGG
GUU
GCU
GAU
GUC
GUA
GUG
GCC
Valine (V)
-Alanine (A)
GCA
GCG
GAC
GAA
GAG
Aspartic acid
(D)
GGU
Glutamic acid
(E)
GGC
GGA
GGG
Glycine (G)
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Chapter 4 Solutions
Genetics: From Genes to Genomes, 5th edition
Ch. 4 - Choose the best matching phrase in the right...Ch. 4 - Humans have 46 chromosomes in each somatic cell....Ch. 4 - The figure that follows shows the metaphase...Ch. 4 - XX males who are sex-reversed because they have a...Ch. 4 - Researchers discovered recently that the sole...Ch. 4 - One oak tree cell with 14 chromosomes undergoes...Ch. 4 - Indicate which of the cells numbered iv matches...Ch. 4 - a. What are the four major stages of the cell...Ch. 4 - Answer the questions that follow for each stage of...Ch. 4 - Does any reason exist that would prevent mitosis...
Ch. 4 - One oak tree cell with 14 chromosomes undergoes...Ch. 4 - Which types of cell division mitosis, meiosis I,...Ch. 4 - Complete the following statements using as many of...Ch. 4 - The five cells shown in figure a e on the next...Ch. 4 - One of the first microscopic observations of...Ch. 4 - A person is simultaneously heterozygous for two...Ch. 4 - Assuming i that the two chromosomes in homologous...Ch. 4 - In the moss Polytrichum commune, the haploid...Ch. 4 - Does any reason exist that would prevent meiosis...Ch. 4 - Sister chromatids are held together through...Ch. 4 - The pseudoautosomal regions PARs of the X and Y...Ch. 4 - Somatic cells of chimpanzees contain 48...Ch. 4 - In humans: a. How many sperm develop from 100...Ch. 4 - Women sometimes develop benign tumors called...Ch. 4 - In a certain strain of turkeys, unfertilized eggs...Ch. 4 - Imagine you have two pure-breeding lines of...Ch. 4 - A system of sex determination known as...Ch. 4 - In Drosophila, the autosomal recessive brown eye...Ch. 4 - Barred feather pattern is a Z-linked dominant...Ch. 4 - When Calvin Bridges observed a large number of...Ch. 4 - In a vial of Drosophila, a research student...Ch. 4 - In 1919, Calvin Bridges began studying an X-linked...Ch. 4 - In Drosophila, a cross was made between a...Ch. 4 - As we learned in this chapter, the white mutation...Ch. 4 - The following is a pedigree of a family in which a...Ch. 4 - Each of the four pedigrees that follow represents...Ch. 4 - The pedigree that follows indicates the occurrence...Ch. 4 - Duchenne muscular dystrophy DMD is caused by a...Ch. 4 - The X-linked gene responsible for DMD encodes a...Ch. 4 - Males have hemophilia when they are hemizygous for...Ch. 4 - Consider the following pedigrees from human...Ch. 4 - Several different antigens can be detected in...Ch. 4 - The ancestry of a white female tiger bred in a...Ch. 4 - The pedigree at the bottom of the page shows the...Ch. 4 - In 1995, doctors reported a Chinese family in...Ch. 4 - In cats, the dominant 0 allele of the X-linked...Ch. 4 - In marsupials like the opposum or kangaroo, X...Ch. 4 - The pedigree diagram below shows a family in which...
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