Genetics: From Genes to Genomes, 5th edition

5th Edition

ISBN: 9780073525310

Author: Leland H. Hartwell, Michael L. Goldberg, Janice A. Fischer, Leroy Hood, Charles F. Aquadro

Publisher: McGraw-Hill Education

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Genomic studies (genomics) is the study of the whole genome of an organism. Using bioinformatics and high-performance computing, genomic researchers examined massive amounts of deoxyribonucleic acid (DNA)-sequence data to discover variations or mutations…

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Chapter 4, Problem 20P

Sister chromatids are held together through metaphase of mitosis by complexes of cohesin proteins that form rubber band–like rings bundling the two sister chromatids. Cohesin rings are found both at centromeres and at many locations scattered along the length of the chromosomes. The rings are destroyed by protease enzymes at the beginning of anaphase, allowing the sister chromatids to separate.

a.	Cohesin complexes between sister chromatids are also responsible for keeping homologous chromosomes together until anaphase of meiosis I. With this point in mind, which of the two diagrams that follow (i or ii) properly represents the arrangement of chromatids during prophase through metaphase of meiosis I? Explain.
b.	What does your answer to part (a) allow you to infer about the nature of cohesin complexes at the centromere versus those along the chromosome arms? Suggest a molecular hypothesis to explain your inference.

Chapter 4, Problem 20P, Sister chromatids are held together through metaphase of mitosis by complexes of cohesin proteins

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Chapter 4, Problem 19P

Chapter 4, Problem 21P

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Chapter 4 Solutions

Genetics: From Genes to Genomes, 5th edition

Ch. 4 - Choose the best matching phrase in the right...Ch. 4 - Humans have 46 chromosomes in each somatic cell....Ch. 4 - The figure that follows shows the metaphase...Ch. 4 - XX males who are sex-reversed because they have a...Ch. 4 - Researchers discovered recently that the sole...Ch. 4 - One oak tree cell with 14 chromosomes undergoes...Ch. 4 - Indicate which of the cells numbered iv matches...Ch. 4 - a. What are the four major stages of the cell...Ch. 4 - Answer the questions that follow for each stage of...Ch. 4 - Does any reason exist that would prevent mitosis...

Ch. 4 - One oak tree cell with 14 chromosomes undergoes...Ch. 4 - Which types of cell division mitosis, meiosis I,...Ch. 4 - Complete the following statements using as many of...Ch. 4 - The five cells shown in figure a e on the next...Ch. 4 - One of the first microscopic observations of...Ch. 4 - A person is simultaneously heterozygous for two...Ch. 4 - Assuming i that the two chromosomes in homologous...Ch. 4 - In the moss Polytrichum commune, the haploid...Ch. 4 - Does any reason exist that would prevent meiosis...Ch. 4 - Sister chromatids are held together through...Ch. 4 - The pseudoautosomal regions PARs of the X and Y...Ch. 4 - Somatic cells of chimpanzees contain 48...Ch. 4 - In humans: a. How many sperm develop from 100...Ch. 4 - Women sometimes develop benign tumors called...Ch. 4 - In a certain strain of turkeys, unfertilized eggs...Ch. 4 - Imagine you have two pure-breeding lines of...Ch. 4 - A system of sex determination known as...Ch. 4 - In Drosophila, the autosomal recessive brown eye...Ch. 4 - Barred feather pattern is a Z-linked dominant...Ch. 4 - When Calvin Bridges observed a large number of...Ch. 4 - In a vial of Drosophila, a research student...Ch. 4 - In 1919, Calvin Bridges began studying an X-linked...Ch. 4 - In Drosophila, a cross was made between a...Ch. 4 - As we learned in this chapter, the white mutation...Ch. 4 - The following is a pedigree of a family in which a...Ch. 4 - Each of the four pedigrees that follow represents...Ch. 4 - The pedigree that follows indicates the occurrence...Ch. 4 - Duchenne muscular dystrophy DMD is caused by a...Ch. 4 - The X-linked gene responsible for DMD encodes a...Ch. 4 - Males have hemophilia when they are hemizygous for...Ch. 4 - Consider the following pedigrees from human...Ch. 4 - Several different antigens can be detected in...Ch. 4 - The ancestry of a white female tiger bred in a...Ch. 4 - The pedigree at the bottom of the page shows the...Ch. 4 - In 1995, doctors reported a Chinese family in...Ch. 4 - In cats, the dominant 0 allele of the X-linked...Ch. 4 - In marsupials like the opposum or kangaroo, X...Ch. 4 - The pedigree diagram below shows a family in which...

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Solution Summary: The author explains how cohesin complexes are important for gene expression, DNA repair, and genome integrity.

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