ANATOMY AND PHYSIOLOGY
17th Edition
ISBN: 9781630180928
Author: OpenStax
Publisher: OPENSTAX C
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Chapter 4, Problem 3ILQ
Visit this link (http://openstaxcollege.org/l/10quiz) to test your connective tissue knowledge with this 10-question quiz. Can you name the 10 tissue types shown in the histology slides?
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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine:
(a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip
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2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0
Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present. Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…
The current nutrition labelling regulation in Hong Kong requires food manufacturer to list E+7 information on the package of pre-packaged food products. Do you think that more nutrients, such as calcium and cholesterol, shall be included?
Chapter 4 Solutions
ANATOMY AND PHYSIOLOGY
Ch. 4 - View this slideshow...Ch. 4 - Watch this video...Ch. 4 - Visit this link...Ch. 4 - Watch this video...Ch. 4 - Follow this link...Ch. 4 - Watch this video...Ch. 4 - Watch this video...Ch. 4 - Which of the following is not a type of tissue?...Ch. 4 - The process by which a less specialized cell...Ch. 4 - Differentiated cells in a developing embryo derive...
Ch. 4 - Which of the following lines the body cavities...Ch. 4 - In observing epithelial cells under a microscope,...Ch. 4 - Which of the following is the epithelial tissue...Ch. 4 - Which type of epithelial tissue specializes in...Ch. 4 - The ________ exocrine gland stores its secretion...Ch. 4 - Connective tissue is made of which three essential...Ch. 4 - Under the microscope, a tissue specimen shows...Ch. 4 - Which connective tissue specializes in storage of...Ch. 4 - Ligaments connect bones together and withstand a...Ch. 4 - In adults, new connective tissue cells originate...Ch. 4 - In bone, the main cells are ________. fibroblasts...Ch. 4 - Striations, cylindrical cells, and multiple nuclei...Ch. 4 - The cells of muscles, myocytes, develop from...Ch. 4 - Skeletal muscle is composed of very hard working...Ch. 4 - The cells responsible for the transmission of the...Ch. 4 - The nerve impulse travels down a(n) ________, away...Ch. 4 - Which of the following central nervous system...Ch. 4 - Which of the following processes is not a cardinal...Ch. 4 - When a mast cell reacts to an irritation, which of...Ch. 4 - Atrophy refers to ________. loss of elasticity...Ch. 4 - Individuals can slow the rate of aging by...Ch. 4 - Identify the four types of tissue in the body, and...Ch. 4 - The zygote is described as totipotent because it...Ch. 4 - What is the function of synovial membranes?Ch. 4 - The structure of a tissue usually is optimized for...Ch. 4 - One of the main functions of connective tissue is...Ch. 4 - Why does an injury to cartilage, especially...Ch. 4 - You are watching cells in a dish spontaneously...Ch. 4 - Why does skeletal muscle look striated?Ch. 4 - Which morphological adaptations of neurons make...Ch. 4 - What are the functions of astrocytes?Ch. 4 - Why is it important to watch for increased...Ch. 4 - Aspirin is a non-steroidal anti-inflammatory drug...Ch. 4 - As an individual ages, a constellation of symptoms...Ch. 4 - Discuss changes that occur in cells as a person...
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